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Table 4 Prognostic accuracy of sepsis criteria in hematology oncology and HCT patients with suspected infection

From: Outcomes of hospitalized hematologic oncology patients receiving rapid response system activation for acute deterioration

Variables All hematology oncology patients (n = 318) HCT patients (n = 122)
Suspected source of infection, n (%)
 Pulmonary 151 (47.5) 55 (45.1)
 Gastrointestinal 89 (28.0) 37 (30.3)
 Urinary tract 35 (11.0) 13 (10.7)
 Skin/soft tissue 10 (3.1) 4 (3.3)
 Central nervous system 6 (1.9) 3 (2.5)
 Other/unknown 27 (8.5) 10 (8.2)
Disease severity, median (IQR)
 Total SOFA score 3 (1–5) 3 (2–5)
 Respiratory SOFA score 1 (0–3) 1 (0–3)
 Coagulation SOFA score 1 (0–1) 1 (1–2)
 Liver SOFA score 0 (0–0) 0 (0–0)
 Cardiovascular SOFA score 1 (1–3) 1 (1–3)
 Central nervous system SOFA score 0 (0–1) 0 (0–1)
 Renal SOFA score 1 (0–2) 1 (0–2)
SIRS criteria
 Sensitivity, % (95% CI) 86.9 (80.9–91.6) 92.5 (81.8–97.9)
 Specificity, % (95% CI) 38.2 (31.9–44.8) 25.0 (16.6–35.1)
 Positive predictive value, % (95% CI) 50.3 (47.4–53.3) 41.5 (38.2–44.5)
 Negative predictive value, % (95% CI) 80.2 (72.6–86.1) 85.2 (67.8–94.0)
 Positive likelihood ratio (95% CI) 1.41 (1.25–1.58) 1.23 (1.07–1.42)
 Negative likelihood ratio (95% CI) 0.34 (0.22–0.52) 0.30 (0.11–0.83)
qSOFA criteria
 Sensitivity, % (95% CI) 61.9 (54.1–69.3) 64.2 (49.8–76.9)
 Specificity, % (95% CI) 91.4 (87.1–94.7) 88.0 (79.6–93.9)
 Positive predictive value, % (95% CI) 83.9 (77.1–88.9) 75.6 (63.2–84.8)
 Negative predictive value, % (95% CI) 76.9 (73.2–80.2) 81.0 (74.7–86.0)
 Positive likelihood ratio (95% CI) 7.21 (4.67–11.15) 5.37 (2.97–9.68)
 Negative likelihood ratio (95% CI) 0.42 (0.34–0.51) 0.41 (0.28–0.59)
  1. Abbreviations: CI confidence interval, IQR interquartile range, SOFA Sequential Organ Failure Assessment