Suspected source of infection, n (%)
|
Pulmonary
|
151 (47.5)
|
55 (45.1)
|
Gastrointestinal
|
89 (28.0)
|
37 (30.3)
|
Urinary tract
|
35 (11.0)
|
13 (10.7)
|
Skin/soft tissue
|
10 (3.1)
|
4 (3.3)
|
Central nervous system
|
6 (1.9)
|
3 (2.5)
|
Other/unknown
|
27 (8.5)
|
10 (8.2)
|
Disease severity, median (IQR)
|
Total SOFA score
|
3 (1–5)
|
3 (2–5)
|
Respiratory SOFA score
|
1 (0–3)
|
1 (0–3)
|
Coagulation SOFA score
|
1 (0–1)
|
1 (1–2)
|
Liver SOFA score
|
0 (0–0)
|
0 (0–0)
|
Cardiovascular SOFA score
|
1 (1–3)
|
1 (1–3)
|
Central nervous system SOFA score
|
0 (0–1)
|
0 (0–1)
|
Renal SOFA score
|
1 (0–2)
|
1 (0–2)
|
SIRS criteria
|
Sensitivity, % (95% CI)
|
86.9 (80.9–91.6)
|
92.5 (81.8–97.9)
|
Specificity, % (95% CI)
|
38.2 (31.9–44.8)
|
25.0 (16.6–35.1)
|
Positive predictive value, % (95% CI)
|
50.3 (47.4–53.3)
|
41.5 (38.2–44.5)
|
Negative predictive value, % (95% CI)
|
80.2 (72.6–86.1)
|
85.2 (67.8–94.0)
|
Positive likelihood ratio (95% CI)
|
1.41 (1.25–1.58)
|
1.23 (1.07–1.42)
|
Negative likelihood ratio (95% CI)
|
0.34 (0.22–0.52)
|
0.30 (0.11–0.83)
|
qSOFA criteria
|
Sensitivity, % (95% CI)
|
61.9 (54.1–69.3)
|
64.2 (49.8–76.9)
|
Specificity, % (95% CI)
|
91.4 (87.1–94.7)
|
88.0 (79.6–93.9)
|
Positive predictive value, % (95% CI)
|
83.9 (77.1–88.9)
|
75.6 (63.2–84.8)
|
Negative predictive value, % (95% CI)
|
76.9 (73.2–80.2)
|
81.0 (74.7–86.0)
|
Positive likelihood ratio (95% CI)
|
7.21 (4.67–11.15)
|
5.37 (2.97–9.68)
|
Negative likelihood ratio (95% CI)
|
0.42 (0.34–0.51)
|
0.41 (0.28–0.59)
|