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Table 4 Prognostic accuracy of sepsis criteria in hematology oncology and HCT patients with suspected infection

From: Outcomes of hospitalized hematologic oncology patients receiving rapid response system activation for acute deterioration

VariablesAll hematology oncology patients (n = 318)HCT patients (n = 122)
Suspected source of infection, n (%)
 Pulmonary151 (47.5)55 (45.1)
 Gastrointestinal89 (28.0)37 (30.3)
 Urinary tract35 (11.0)13 (10.7)
 Skin/soft tissue10 (3.1)4 (3.3)
 Central nervous system6 (1.9)3 (2.5)
 Other/unknown27 (8.5)10 (8.2)
Disease severity, median (IQR)
 Total SOFA score3 (1–5)3 (2–5)
 Respiratory SOFA score1 (0–3)1 (0–3)
 Coagulation SOFA score1 (0–1)1 (1–2)
 Liver SOFA score0 (0–0)0 (0–0)
 Cardiovascular SOFA score1 (1–3)1 (1–3)
 Central nervous system SOFA score0 (0–1)0 (0–1)
 Renal SOFA score1 (0–2)1 (0–2)
SIRS criteria
 Sensitivity, % (95% CI)86.9 (80.9–91.6)92.5 (81.8–97.9)
 Specificity, % (95% CI)38.2 (31.9–44.8)25.0 (16.6–35.1)
 Positive predictive value, % (95% CI)50.3 (47.4–53.3)41.5 (38.2–44.5)
 Negative predictive value, % (95% CI)80.2 (72.6–86.1)85.2 (67.8–94.0)
 Positive likelihood ratio (95% CI)1.41 (1.25–1.58)1.23 (1.07–1.42)
 Negative likelihood ratio (95% CI)0.34 (0.22–0.52)0.30 (0.11–0.83)
qSOFA criteria
 Sensitivity, % (95% CI)61.9 (54.1–69.3)64.2 (49.8–76.9)
 Specificity, % (95% CI)91.4 (87.1–94.7)88.0 (79.6–93.9)
 Positive predictive value, % (95% CI)83.9 (77.1–88.9)75.6 (63.2–84.8)
 Negative predictive value, % (95% CI)76.9 (73.2–80.2)81.0 (74.7–86.0)
 Positive likelihood ratio (95% CI)7.21 (4.67–11.15)5.37 (2.97–9.68)
 Negative likelihood ratio (95% CI)0.42 (0.34–0.51)0.41 (0.28–0.59)
  1. Abbreviations: CI confidence interval, IQR interquartile range, SOFA Sequential Organ Failure Assessment