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Table 1 Genes and associated single nucleotide polymorphisms (SNPs) related to influenza A susceptibility in humans

From: Host susceptibility to severe influenza A virus infection

 Gene Gene name Function SNP Reference
Entry factors/cell membrane
 IFITM3 Interferon-induced transmembrane protein 3 Antiviral rs12252-C [64,65,66]
rs34481144-A [67]
 CD55 Complement decay-accelerating factor precursor 55 Inhibition of complement activation rs2564978 T/T [71, 72]
 TMPRSS2 Transmembrane protease, serine 2 Serine protease rs2070788 GG [73,74,75,76]
 GLDC Glycine decarboxylase Component of the glycine cleavage system rs1755609-G [80]
 LGALS1 Galectin-1 Cell-cell interactions rs4820294 [82]
rs2899292 [82]
rs4820294 [82]
 ST3GAL1 (*) ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Transfer of sialic acids to galactose-containing substrates rs113350588 [90]
rs1048479 [90]
 TNFA (*) Tumour necrosis factor alpha Inflammation and immune signalling rs361525-A [91]
 TLR3 (*) Toll-like Receptor 3 Pathogen recognition rs5743313-CT [92]
rs5743313-CC [72]
Surfactant proteins
 SP-A2 (*) Pulmonary-surfactant associated protein A2 Pathogen binding and immune signalling rs1965708-C [89]
rs1059046-A [89]
 SP-B Pulmonary-surfactant associated protein B Pathogen binding and immune signalling rs1130866 [77]
 IL1A (*) Interleukin 1 alpha Inflammation and immune signalling rs17561-T [84]
 IL1B (*) Interleukin 1 beta Inflammation and immune signalling rs1143627-C [84]
rs16944-AG [85]
rs3136558-TC [85]
 IL28B Interleukin 28 b, IFN-λ 3 Immunomodulation rs8099917-TT [86]
 IL17 (*) Interleukin 17 Inflammation and immune signalling rs2275913 (GG and AG) [87]
 IL6 (*) Interleukin 6 Inflammation and immune signalling rs1818879-(GA and GG) [85, 88]
  1. Gene: gene symbol. Gene name: gene name and alternate name. Function: summary function of gene product. SNP: SNPs associated with host susceptibility to influenza A associated with gene. (*) represents genes not addressed in the text