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Table 3 Diagnostic performances to predict CRT and cardiac index responsiveness

From: Capillary refill time variation induced by passive leg raising predicts capillary refill time response to volume expansion

  Index test AUC [95% CI] Best threshold Specificity Sensitivity PPV NPV Youden index
Peripheral perfusion response (decrease of 25% of CRT after VE) ΔCRT-PLR 0.94 [0.87–1.0] − 27% [− 30, − 18] 1.00 [0.74–1.00] 0.87 [0.73–1.0] 1.0 [0.72–1.0] 0.91 [0.79–1.0] 0.87
PCO2gap 0.79 [0.61–0.93] 1.2 kPa [0.9–1.6] 0.73 [0.53–0.93] 0.79 [0.57–1.00] 0.72 [0.58–0.92] 0.79 [0.62–1.00] 0.52
Baseline CRT 0.73 [0.54–0.90] 2.7 s [2.6–4.1] 0.74 [0.47–1.0] 0.80 [0.47–1.00] 0.69 [0.54–1.00] 0.67 [0.8–1.00] 0.49
Cardiac index response (increase of 15% of CI) ΔCI-PLR 0.95 [0.86–1.00] 9.0% [8.7–13.7] 0.90 [0.71–1.00] 1.00 [0.77–1.00] 0.85 [0.68–1.00] 1.00 [0.86–1] 0.90
  1. ROCAUC area under the receiving operating characteristic curves, CRT capillary refill time, VE volume expansion, ΔCRT-PLR variation of CRT induced by passive leg raising (PLR), ΔCI-PLR variation of cardiac index induced by PLR, NPV negative predictive value, PPV positive predictive value