Harmful effects of mechanical ventilation on neurocognitive functions

Table 1 Mechanisms of MV-induced brain damage

Alveolar stretching	Systemic and cerebral mediators of neuroinflammation	Systemic release of lung-produced inflammatory mediators (“biotrauma”)
		Local activation of brain inflammatory mediators
		Immunomediated: Toll-like receptor expression
	Afferent neuronal signal: DRD2
	Beta amyloid production
PaO₂/PaCO₂ abnormalities	Hypo/hyperoxia
	Hypo/hypercapnia

Alveolar stretching—through mechanotransduction—induces neuroinflammation with the release of mediators

ISSN: 1364-8535