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Table 3 Reported ROC values of the included studies

From: Functional hemodynamic tests: a systematic review and a metanalysis on the reliability of the end-expiratory occlusion test and of the mini-fluid challenge in predicting fluid responsiveness

 StudiesFunctional hemodynamic testParameterAUC (95%CI)Sensitivity (%)Specificity (%)Y+PV−PV+LR−LRThresholdGZ highGZ lowPt in GZ (%)
Operating roomGuinot et al. [33]EEOT: ventilation interrupted for 15 sDELTA SV (%)0.78 (0.63–0.89)8271NA85672.870.252.3NANANA
Biais et al. [34]EEOT: ventilation interrupted for 30 sDELTA SV (%)0.91 (0.81–1.0)100810.8184100NANA58417
Biais et al. [35]Mini-FC: 100 ml in 120 sDELTA SV (%)0.95 (0.90–0.99)93850.78NANANANA67419
Guinot et al. [36]Mini-FC: 100 ml in 60 sDELTA SV (%)0.93 (0.84–0.97)8989NA83938.180.1278314
Preisman et al. [37]RSVT: decrease in SAP after successive incremental pressure-controlled breaths (10, 20, and 30 cmH2O)RSVT (slope, mmHg/cmH2O)0.96 (0.92–1.0)9389NANANANANA0.51NANANA
Biais et al. [38]LRM: 30 cmH20/30 sDELTA SV (%)0.96 (0.81–0.99)8892NANANANANA30− 22− 3736
De Broca et al. [39]LRM: 25 cmH20/25 sDELTA SV (%)0.95 (0.91–0.99)92960.9210089NANA16− 15− 178
Intensive care unitWu et al. [40]Mini-FC: 50 ml in 10 sDELTA VTI (%)0.83 (0.69–0.96)7495NA9479NANA9NANANA
Smorenberg et al. [41]Mini-FC: 100 ml in 120 sDELTA CO (%)0.85 (0.63–0.97)NANANA9288NANA2.3NANANA
Muller et al. [29]Mini-FC: 100 ml in 60 sDELTA VTI (%)0.92 (0.78–0.98)9578NANANANANA3NANANA
Monge Garcia et al. [42]Airway pressure elevated up to 30 cmH20 for 10 sDELTA PP (%)0.98 (0.84–0.99)9195NA9195NANA52NANANA
Perel et al. [28]RSVT: decrease in SAP after successive incremental pressure-controlled breaths (5,10, 15, and 20 cmH2O)RSVT (slope, mmHg/cmH2O)0.89 (0.72–1.0)87.583NANANANANA0.24NANANA
Yonis et al. [43]EEOT: ventilation interrupted for 15 sDELTA CI (%)0.65 (0.46–0.84)33100NANANAINF0.671011− 479
Yonis et al. [43]Trendelemburg maneuverDELTA CI (%)0.9 (0.8–1.0)8789NANANA7.90.15812530
Xiao-ting et al. [44]Mini-FC: 100 ml in 60 sDELTA CI (%)0.83 (0.69–0.96)73.260.6NANANANANA5.4NANANA
Mallat et al. [45]Mini-FC: 100 ml in 60 sDELTA CI (%)0.78 (0.64–0.88)7774NANANANANA5.212.6− 1.567
Georges et al. [46]EEOT: ventilation interrupted for 12 sDELTA VTI (%)0.96 ± 0.0389950.85NANANANA910620
Wilkman et al. [47]PEEP elevated from 10 to 20 cmH2O for 60–120 sDELTA MAP (%)0.91 (0.77–1.0)8386NA7192NANA− 10.2NANANA
Jozwiak et al. [48]EEOT: ventilation interrupted for 15 sDELTA CI (%)0.98 (0.85–1.0)931000.93NANANANA4NANANA
Monnet et al. [23]EEOT: ventilation interrupted for 15 sDELTA CI (%)0.97 (0.85–0.99)91100NANANANANA5NANANA
Myatra et al. [49]Vt raised up from 6 to 8 ml/kg for 1 minDELTA PPV (%)0.99 (0.98–1.0)94100NA10093NANA3.5NANANA
Myatra et al. [49]Vt raised up from 6 to 8 ml/kg for 1 minDELTA SVV (%)0.97 (0.92–1.0)88100NA10088NANA2.5NANANA
Myatra et al. [49]EEOT: ventilation interrupted for 15 s (6 ml/kg ventilation)DELTA CI (%)0.44 (0.23–0.66)NANANANANANANANANANANA
Myatra et al. [49]EEOT: ventilation interrupted for 15 s (8 ml/kg ventilation)DELTA CI (%)0.95 (0.88–1.0)8893NA9378NANA4.1NANANA
Monnet et al. [50]EEOT: ventilation interrupted for 15 s (Crs < 30 cmH2O/ml)DELTA CI (%)0.97 ± 0.0393910.859391NANA5NANANA
Monnet et al. [50]EEOT: ventilation interrupted for 15 s (Crs > 30 cmH2O/ml)DELTA CI (%)0.93 ± 0.0593920.849392NANA5NANANA
  1. The area under the receiving operating characteristic (ROC) curve (AUC) of each study is reported as median (25th–75th interquartile) or mean (± standard deviation), as stated in the original article
  2. NA data not available, CI cardiac index, CO cardiac output, SV stroke volume, SVI stroke volume index, SVV stroke volume variation, PPV pulse pressure variation, VTI velocity time integral, RSVT respiratory systolic variation test, PP pulse pressure, MAP mean arterial pressure, SAP systolic arterial pressure, ND not defined, Vt tidal volume, Crs respiratory compliance, EEOT end-expiratory occlusion test, LRM lung recruitment maneuver, RSVT respiratory systolic variation test, PEEP positive end-expiratory pressure, FC fluid challenge, Y Youden index, +PV positive predictive value, −PV negative predictive value, +LR positive likelihood ration, −LR negative likelihood ratio, GZ gray zone, Pt patients, INF infinite