Effects of sedatives and opioids on trigger and cycling asynchronies throughout mechanical ventilation: an observational study in a large dataset from critically ill patients

Table 2 Mean estimated effect from the regression coefficient of SAS and SOFA on asynchronies, by treatment group

Treatment group	Asynchrony Index	Ineffective inspiratory efforts during expiration	Double cycling
SAS
No drugs	− 0.10 (− 0.29, 0.10) p = 0.34	− 0.14 (− 0.36, 0.09) p = 0.24	− 0.02 (− 0.25, 0.21) p = 0.87
Sedatives	0.11 (− 0.09, 0.31) p = 0.29	− 0.04 (− 0.27, 0.20) p = 0.76	0.46 (0.23, 0.69) p < 0.0001
Opioids	− 0.17 (− 0.37, 0.04) p = 0.12	− 0.20 (− 0.44, 0.04) p = 0.10	0.08 (− 0.18, 0.33) p = 0.55
Sedatives + opioids	0.14 (0.03, 0.26) p = 0.17	0.12 (− 0.02, 0.26) p = 0.09	0.30 (0.17, 0.44) p < 0.0001
SOFA
No drugs	0.02 (− 0.03, 0.07) p = 0.38	0.02 (− 0.04, 0.08) p = 0.52	0.08 (0.02, 0.13) p = 0.008
Sedatives	0.02 (− 0.05, 0.09) p = 0.55	0.06 (− 0.02, 0.14) p = 0.17	− 0.03 (− 0.12, 0.05) p = 0.45
Opioids	− 0.06 (− 0.13, 0.02) p = 0.13	− 0.05 (− 0.13, 0.03) p = 0.25	− 0.09 (− 0.17, − 0.01) p = 0.03
Sedatives + opioids	− 0.01 (− 0.05, 0.03) p = 0.66	− 0.00 (− 0.05, 0.05) p = 0.98	− 0.00 (− 0.05, 0.04) p = 0.91

Results are expressed as mean estimated effect and 95% CI. A negative sign indicates an inverse association. Statistically significant associations are indicated
SAS Sedation Assessment Scale, SOFA Sequential Organ Failure Assessment

ISSN: 1364-8535