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Table 2 Subgroup analysis for relative risk (RR) of intervention vs. control

From: Trends in sepsis mortality over time in randomised sepsis trials: a systematic literature review and meta-analysis of mortality in the control arm, 2002–2016

Type of study Number of studies Combined RR (95% CI) p value I2** p value for I2
Early goal-directed therapy 3 0.985 (0.860, 1.127) 0.824 0.0% 0.686
Hemofiltration 2 1.149 (0.840, 1.573) 0.384 44.6% 0.179
Immunomodulation 18 0.996 (0.931, 1.066) 0.917 32.5% 0.090
Modulation of coagulation and inflammation 6 1.113 (1.019, 1.216) 0.018 0.07% 0.600
Other interventions 7 0.912 (0.751, 1.106)* 0.531 80.3% < 0.001
Plasmapheresis 1 0.995 (0.702, 1.410) 0.978   
Vasoactive drugs 4 0.916 (0.804, 1.044) 0.189 0.0% 0.447
Fluid resuscitation 3 1.019 (0.897, 1.159) 0.769 0.0% 0.593
  1. *Random effects model was used
  2. **I2 measures the statistical heterogeneity across the studies