Fig. 4
From: Alterations of the iNKT cell compartment in brain-injured patients
Cytokine secretion after specific activation of iNKT cells in BI patients’ sera and adrenergic receptor β2 (ADRB2) expression. a iNKT cells isolated from a healthy donor were stimulated with α-GalCer loaded on PBMCs from 8 healthy volunteers (HV), in medium containing pooled serum from 40 HV or sera from 20 BI patients. Cytokines were measured in supernatants by ELISA after 48 h. Data are shown as the percentage of each secreted cytokine when BI’s serum was used, 100% corresponding to the secretion in the presence of HV serum (horizontal dashed bar). Graphic is representative of two independent experiments. b Expression of the ADRB2 on the surface of CD3+ lymphocytes. Data are shown as the percentage of positive cells for 5 HV and 10 BI patients. Top and down whiskers represent the 25th percentile, the median, and the 75th percentile (**p < 0.01, ***p < 0.001; statistical analysis, Mann-Whitney test)