Fig. 1

Comparison of MMP8 expression, MMP-8 plasma levels, and procalcitonin in consecutively enrolled patients treated for suspected community-acquired pneumonia (CAP) upon intensive care unit admission. a Box-and-whisker and dot plots depicting MMP8 expression in CAP (n = 86) and no-CAP patients (non-infectious control, n = 31). The dotted line represents MMP8 median expression in age-matched healthy volunteers (n = 42). b Box-and-whisker and dot plots depicting MMP-8 plasma levels in CAP and no-CAP patients. The dotted lines indicate median values obtained in 27 age-matched healthy subjects. c Correlation between MMP8 expression and MMP8 plasma levels in patients admitted for a suspected CAP. d Comparison of MMP8 expression or plasma levels with procalcitonin in patients consecutively admitted to the ICU for a suspicion of CAP (cohort A). Receiver operating characteristic analysis. AUC, area under the curve. e Assessment of the MMP8 plasma biomarker in an independent cohort (Validation cohort) of CAP (n = 57) and no-CAP patients (n = 26). Receiver operating characteristic analysis AUC