Parameter | Structural model (RSE%) [shrinkage%] | Final model | ||
---|---|---|---|---|
Final model (RSE%) [shrinkage%] | Bootstrap (5000 replicates) | |||
Median | 95% CI (2.5–97.5%) | |||
Fixed effects | ||||
 ΘCL | 39.5 (11) | 37.8 (3) | 37.4 | 27.0, 47.8 |
 ΘV1 | 220 (23) | 229 (10) | 223 | 66.2, 352 |
 ΘV2 | 1620 (26) | 1640 (9) | 1629 | 755, 4304 |
 ΘQ | 35.8 (17) | 41 (12) | 42.1 | 21.5, 67.6 |
 ΘTemp | – | 0.207 (5) | 0.21 | 0.066, 0.437 |
 ΘT.Prot | – | 2.46 (7) | 2.51 | 0.892, 5.12 |
Random effects | ||||
 Inter-individual variability | ||||
 ωCL2 | 0.196 (46) [15] | 0.167 (57) [20] | 0.197 | 0.03, 0.484 |
 ωV22 | 1.41 (35) [21] | 1.13 (48) [22] | 0.968 | 0.081, 2.08 |
 Residual variability | ||||
 σ2proportional | 0.0915 (19) [10] | 0.0841 (5) [9] | 0.0743 | 0.047, 0.116 |