Skip to main content

Table 2 Parameter estimates and bootstrap confidence intervals

From: Population pharmacokinetics of intravenous sufentanil in critically ill patients supported with extracorporeal membrane oxygenation therapy

Parameter

Structural model (RSE%) [shrinkage%]

Final model

Final model (RSE%) [shrinkage%]

Bootstrap (5000 replicates)

Median

95% CI (2.5–97.5%)

Fixed effects

 ΘCL

39.5 (11)

37.8 (3)

37.4

27.0, 47.8

 ΘV1

220 (23)

229 (10)

223

66.2, 352

 ΘV2

1620 (26)

1640 (9)

1629

755, 4304

 ΘQ

35.8 (17)

41 (12)

42.1

21.5, 67.6

 ΘTemp

–

0.207 (5)

0.21

0.066, 0.437

 ΘT.Prot

–

2.46 (7)

2.51

0.892, 5.12

Random effects

 Inter-individual variability

 ωCL2

0.196 (46) [15]

0.167 (57) [20]

0.197

0.03, 0.484

 ωV22

1.41 (35) [21]

1.13 (48) [22]

0.968

0.081, 2.08

 Residual variability

 σ2proportional

0.0915 (19) [10]

0.0841 (5) [9]

0.0743

0.047, 0.116

  1. RSE%, relative standard error; RSE% = (standard error/parameter estimate) × 100; CL, systemic clearance; V1, central volume of distribution; V2, peripheral volume of distribution; Q, intercompartmental clearance