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Table 1 Characteristics of the study patients

From: Population pharmacokinetics of intravenous sufentanil in critically ill patients supported with extracorporeal membrane oxygenation therapy

 

Number/median (range) (n = 20)

Age (years)

55 (23–88)

Male

16

Body weight (kg)

69.4 (52.9–92.5)

Lean body weight (kg)

55.3 (36.8–58.6)

Body mass index (kg m−2)

24.7 (20.5–31.8)

Indication for VA-ECMO

 Acute myocardial infarction

4

 ST-elevation myocardial infarction

12

 Non-ST-elevation myocardial infarction

4

APACHE II

29 (15–36)

Time between onset of MI and initiation of ECMO (h)

2 (0.5–12)

Blood chemistry, serum levels

 Total plasma protein (g dL−1)

4.5 (2.1–6)

 Total bilirubin (mg dL−1)

1.9 (0.3–6.6)

 Blood urea nitrogen (mg dL−1)

21.3 (7.5–58)

 Serum creatinine (mg dL−1)

1.4 (0.4–4.9)

Partial pressure of carbon dioxide (mmHg)

29.1 (13.5–46.7)

Tympanic body temperature (°C)

36.9 (33–38.7)

Use of continuous venovenous hemodiafiltration

9

Duration of VA-ECMO (h)

138 (52.9–263)

ECMO flow rate (L min−1)

3 (0.6–4.1)

Duration of sufentanil infusion (h)

110 (34–260)

Sufentanil infusion rate

 17.5 μg h−1

15

 12.5 μg h−1

5