Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones

Table 1 Survival until day 5 of septic mice in the different mouse cohorts

	Randomization	5-day survival (number, %)	p value
Study 1: Fatty acid mobilization and metabolism in lean and obese septic mice	Lean	15/18 (83)	1.0
	Obese	15/18 (83)	1.0
Study 2: Effect of blocking fatty acid mobilization in obese septic mice on the muscle	Wild-type	19/22 (86)	0.1
	AAKO	17/25 (68)	0.1
Study 3: Effect of increased lipid availability on the muscle in lean septic mice	PN	23/25 (92)	0.8
	Lipid PN	23/26 (88)	0.8
Study 4: Effect of increased ketone body availability on the muscle in lean septic mice	PN+gluc	17/20 (85)	0.8
	PN+3-HB	17/21 (81)	0.8

In all healthy control groups and day 1 septic mice, survival was 100%. [AAKO adipose tissue-specific adipose triglyceride lipase knockout, PN parenteral nutrition, Lipid PN parenteral nutrition consisting mainly of long- and medium-chain triglycerides, PN+gluc mice receiving PN supplemented with glucose, PN+3-HB mice receiving PN supplemented with ketone body 3-hydroxybutyrate]

ISSN: 1364-8535