Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

Table 3 Multivariable linear regression model for an association between 24-h NT-proBNP levels and hand grip strength at 6 and 12 months after sepsis*

Effect	Estimate	SE	p value
6-month hand grip strength
Intercept	57.18	3.86	< 0.0001
NT-proBNP (lowest tertile as reference)			0.0015^†
Middle tertile	− 1.63	2.02	0.4222
Highest tertile	− 9.30	2.60	0.0006
Sex (female)	− 16.18	1.88	< 0.0001
Race (non-Caucasian)	2.80	3.41	0.4138
Charlson comorbidity index	− 0.09	0.52	0.8588
Age	− 0.32	0.09	0.0003
CCI^‡	− 3.81	2.29	0.0990
APACHE	− 0.03	0.12	0.8372
12-month hand grip strength
Intercept	56.87	5.21	< 0.0001
NT-proBNP (lowest tertile as reference)			0.0427^†
Middle tertile	− 1.20	2.23	0.5916
Highest tertile	− 8.71	3.61	0.0177
Sex (female)	− 15.61	2.21	< 0.0001
Race (non-Caucasian)	3.65	2.83	0.2010
Charlson comorbidity index	− 0.05	0.62	0.9380
Age	− 0.31	0.12	0.0146
CCI^‡	− 4.00	2.11	0.0617
APACHE	− 0.07	0.11	0.5386

Inverse probability weighting based on concurrent Zubrod scores was used to account for missing follow-up data, as well as absence due to death; NT-proBNP levels: lowest tertile (29–711 ng/L), middle tertile (712–2378 ng/L), and highest tertile (2379–70,000 ng/L)
SE standard error, NT-proBNP N-terminal pro-brain natriuretic peptide, CCI chronic critical illness, APACHE Acute Physiology and Chronic Health Evaluation
^†Overall p value
^‡Rapid recovery (RAP) patients as a reference group

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