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Table 3 Multivariable linear regression model for an association between 24-h NT-proBNP levels and hand grip strength at 6 and 12 months after sepsis*

From: Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

Effect Estimate SE p value
6-month hand grip strength
 Intercept 57.18 3.86 < 0.0001
 NT-proBNP (lowest tertile as reference)    0.0015
  Middle tertile − 1.63 2.02 0.4222
  Highest tertile − 9.30 2.60 0.0006
 Sex (female) − 16.18 1.88 < 0.0001
 Race (non-Caucasian) 2.80 3.41 0.4138
 Charlson comorbidity index − 0.09 0.52 0.8588
 Age − 0.32 0.09 0.0003
 CCI − 3.81 2.29 0.0990
 APACHE − 0.03 0.12 0.8372
12-month hand grip strength
 Intercept 56.87 5.21 < 0.0001
 NT-proBNP (lowest tertile as reference)    0.0427
  Middle tertile − 1.20 2.23 0.5916
  Highest tertile − 8.71 3.61 0.0177
 Sex (female) − 15.61 2.21 < 0.0001
 Race (non-Caucasian) 3.65 2.83 0.2010
 Charlson comorbidity index − 0.05 0.62 0.9380
 Age − 0.31 0.12 0.0146
 CCI − 4.00 2.11 0.0617
 APACHE − 0.07 0.11 0.5386
  1. Inverse probability weighting based on concurrent Zubrod scores was used to account for missing follow-up data, as well as absence due to death; NT-proBNP levels: lowest tertile (29–711 ng/L), middle tertile (712–2378 ng/L), and highest tertile (2379–70,000 ng/L)
  2. SE standard error, NT-proBNP N-terminal pro-brain natriuretic peptide, CCI chronic critical illness, APACHE Acute Physiology and Chronic Health Evaluation
  3. Overall p value
  4. Rapid recovery (RAP) patients as a reference group