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Table 2 Proposed target patient populations for [TIMP-2]•[IGFBP7] testing

From: Clinical use of [TIMP-2]•[IGFBP7] biomarker testing to assess risk of acute kidney injury in critical care: guidance from an expert panel

Tier 1
 • Postoperative cardiovascular surgery
 • Shock/Hemodynamically unstable
 • Sepsis
 • Postoperative major non-cardiovascular surgery
 • Cardiac arrest, extracorporeal membrane oxygenation
 • Oliguria after acute resuscitation
Tier 2
 • Severe trauma (Injury Severity Score > 15)
 • Acute illness/decompensation
 • Elevated serum creatinine and no baseline
 • Decompensated heart failure
 • Acute respiratory distress syndrome/hypoxic respiratory failure
 • Burn patients with total body surface area > 30%
 • Anyone being seen by a rapid response team
 • Solid organ (liver, heart, lung, kidney) transplants
 • Receiving any nephrotoxic medications
 • Any unplanned intensive care unit admission
 • Suspected (impending) stage 2/3 acute kidney injury
 • Volume depleted
 • End-stage liver disease with early acute kidney injury (± hepatorenal syndrome)
 • Post-urologic procedure (e.g., partial / radical nephrectomy or cystectomy)
  1. Populations are listed in order of priority. Priorities assigned to the top three populations were highest among all participants (scores > 35 out of a possible 48). The second tier was also highly ranked (> 20). The remaining populations received lower priority rankings (10–20)