Table 2 Proposed target patient populations for [TIMP-2]•[IGFBP7] testing

Tier 1

 • Postoperative cardiovascular surgery

 • Shock/Hemodynamically unstable

 • Sepsis

 • Postoperative major non-cardiovascular surgery

 • Cardiac arrest, extracorporeal membrane oxygenation

 • Oliguria after acute resuscitation

Tier 2

 • Severe trauma (Injury Severity Score > 15)

 • Acute illness/decompensation

 • Elevated serum creatinine and no baseline

 • Decompensated heart failure

 • Acute respiratory distress syndrome/hypoxic respiratory failure

 • Burn patients with total body surface area > 30%

 • Anyone being seen by a rapid response team

 • Solid organ (liver, heart, lung, kidney) transplants

 • Receiving any nephrotoxic medications

 • Any unplanned intensive care unit admission

 • Suspected (impending) stage 2/3 acute kidney injury

 • Volume depleted

 • End-stage liver disease with early acute kidney injury (± hepatorenal syndrome)

 • Post-urologic procedure (e.g., partial / radical nephrectomy or cystectomy)