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Table 1 Characteristics of included studies

From: Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis

Author and publication year

Years recruiting

Study type

Country

N centres

Centre type

Inc. criteria

n

Male sex

Age

HIV infected

Median CD4 μL− 1

Jacob et al. 2009 [5]

2006

Cohort

Uganda

2

Referral

SII severe sepsis

382

156/382 (41%)

35

320/382 (85%)

52

Nadjm et al. 2012 [25]

2007

Cohort

Tanzania

1

District

Fever and one severity criteria

198

67/198 (34%)

37

69/180 (38%)

NR

Jacob et al. 2012 [34]a and Moore et al. 2018 [23]

2008–2009

Before-after

Uganda

2

Referral

SII severe sepsis

426

207/426 (49%)

34

362/426 (85%)

63

Waitt et al. 2015 [26]

2008–2009

Cohort

Malawi

1

Referral

SII sepsis

213

87/213 (41%)

30

161/213 (76%)

NR

Ssekitoleko et al. 2011 [27]a

2009

Cohort

Uganda

1

Referral

SII sepsis

96

193/418b (46%)

35

331/418b (83%)

NR

Ssekitoleko et al. 2011 [28]

2009

Cohort

Uganda

1

Referral

SII sepsis

150

94/150 (63%)

35

96/150 (64%)

NR

Chimese et al. 2012 [21]

2010

Cohort

Zambia

1

Referral

SII sepsis

161

79/161 (49%)

39

110/138 (80%)

NR

Andrews et al. 2014 [35]

2012

RCT

Zambia

1

Referral

SII severe sepsis

112

58/109 (53%)

35

88/109 (81%)

NR

Auma et al. 2013 [29]

2012

Cohort

Uganda

1

Referral

SII sepsis

216

106/216 (49%)

32

122/216 (56%)

NRe

Andrews et al. 2017 [33]

2012–2013

RCT

Zambia

1

Referral

SII severe sepsis

209

117/209 (56%)

36

187/209 (90%)

66

Huson et al. 2014 [20]

2012–2013

Cohort

Gabon

1

Referral

SII sepsis

107

NA

34

26/107 (24%)

168

Seboxa et al. 2015 [30]

2012–2013

Cohort

Ethiopia

1

Referral

SII sepsis

292

151/292 (52%)

27

40/209 (19%)

NR

Rudd et al. 2017 [31]

2013

Cohort

Uganda

1

District

SII sepsis

20

11/20 (55%)

32

6/20 (30%)

NR

Amir et al. 2016 [24]

2014–2015

Cohort

Uganda

1

Referral

SII severe sepsis

218

110/218 (50%)

35

125/218 (57%)

78

  1. RCT randomised controlled trial, SII Sepsis-2 definition (e.g. SII sepsis is consistent with Sepsis-2 definition). aThese studies also present data from Jacob et al. [5]—only new data is included in this table row. bDisaggregated data are not given for the included 96 patients; HIV prevalence for the total cohort is shown