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Table 1 Characteristics of included studies

From: Aetiology and outcomes of sepsis in adults in sub-Saharan Africa: a systematic review and meta-analysis

Author and publication year Years recruiting Study type Country N centres Centre type Inc. criteria n Male sex Age HIV infected Median CD4 μL− 1
Jacob et al. 2009 [5] 2006 Cohort Uganda 2 Referral SII severe sepsis 382 156/382 (41%) 35 320/382 (85%) 52
Nadjm et al. 2012 [25] 2007 Cohort Tanzania 1 District Fever and one severity criteria 198 67/198 (34%) 37 69/180 (38%) NR
Jacob et al. 2012 [34]a and Moore et al. 2018 [23] 2008–2009 Before-after Uganda 2 Referral SII severe sepsis 426 207/426 (49%) 34 362/426 (85%) 63
Waitt et al. 2015 [26] 2008–2009 Cohort Malawi 1 Referral SII sepsis 213 87/213 (41%) 30 161/213 (76%) NR
Ssekitoleko et al. 2011 [27]a 2009 Cohort Uganda 1 Referral SII sepsis 96 193/418b (46%) 35 331/418b (83%) NR
Ssekitoleko et al. 2011 [28] 2009 Cohort Uganda 1 Referral SII sepsis 150 94/150 (63%) 35 96/150 (64%) NR
Chimese et al. 2012 [21] 2010 Cohort Zambia 1 Referral SII sepsis 161 79/161 (49%) 39 110/138 (80%) NR
Andrews et al. 2014 [35] 2012 RCT Zambia 1 Referral SII severe sepsis 112 58/109 (53%) 35 88/109 (81%) NR
Auma et al. 2013 [29] 2012 Cohort Uganda 1 Referral SII sepsis 216 106/216 (49%) 32 122/216 (56%) NRe
Andrews et al. 2017 [33] 2012–2013 RCT Zambia 1 Referral SII severe sepsis 209 117/209 (56%) 36 187/209 (90%) 66
Huson et al. 2014 [20] 2012–2013 Cohort Gabon 1 Referral SII sepsis 107 NA 34 26/107 (24%) 168
Seboxa et al. 2015 [30] 2012–2013 Cohort Ethiopia 1 Referral SII sepsis 292 151/292 (52%) 27 40/209 (19%) NR
Rudd et al. 2017 [31] 2013 Cohort Uganda 1 District SII sepsis 20 11/20 (55%) 32 6/20 (30%) NR
Amir et al. 2016 [24] 2014–2015 Cohort Uganda 1 Referral SII severe sepsis 218 110/218 (50%) 35 125/218 (57%) 78
  1. RCT randomised controlled trial, SII Sepsis-2 definition (e.g. SII sepsis is consistent with Sepsis-2 definition). aThese studies also present data from Jacob et al. [5]—only new data is included in this table row. bDisaggregated data are not given for the included 96 patients; HIV prevalence for the total cohort is shown