Fig. 2

a In-hospital sepsis mortality. b In-hospital severe sepsis mortality. c 28- or 30-day severe sepsis mortality. In all cases, only studies using a Sepsis-2 definition of sepsis or suspected sepsis are included. Random effects summary estimate from a generalised linear mixed model is shown as well as measures of heterogeneity: τ², I², and p value from Cochran’s Q test