The association between nutritional adequacy and 28-day mortality in the critically ill is not modified by their baseline nutritional status and disease severity

Table 4 Association between energy and protein intakes and 28-day mortality as well as nutritional status stratified by days on exclusive nutritional support and GLIMPSE groups

Parameters	Short-term ENS (≤ 6 days)		Longer-term ENS (≥ 7 days)		p value
Parameters	Low-GLIMPSE* (n = 36)	High-GLIMPSE* (n = 70)	Low-GLIMPSE* (n = 64)	High-GLIMPSE* (n = 82)	p value
Energy intake					0.793^†	0.035^‡
Each 10% of goal	1.24 (0.70–2.20)	1.60 (1.19–2.15)	2.17 (0.75–6.26)	0.83 (0.64–1.12)
	p = 0.462	p = 0.002	p = 0.150	p = 0.228
	GOF = 0.682	GOF = 0.823	GOF = 0.287	GOF = 0.615
Protein intake					0.904^§	0.025**
Each 10% of goal	1.20 (0.68–2.11)	1.47 (1.12–1.86)	1.23 (0.73–2.08)	0.75 (0.57–0.99)
	p = 0.535	p = 0.004	p = 0.428	p = 0.043
	GOF = 0.685	GOF = 0.530	GOF = 0.455	GOF = 0.335
7-point SGA-categories					0.480^††	0.633^‡‡
Well-nourished
SGA-7	22 [61.1]	34 [48.6]	41 [64.1]	34 [41.5]
SGA-6	8 [22.2]	11 [15.7]	18 [28.1]	18 [22.0]
Mildly to moderately malnourished
SGA-5	3 [8.3]	8 [11.4]	4 [6.3]	14 [17.1]
SGA-4	2 [5.6]	7 [10.0]	1 [1.6]	9 [11.0]
SGA-3	1 [2.8]	5 [7.1]	0 [0.0]	5 [6.1]
Severely malnourished
SGA-2		4 [5.7]		2 [2.4]
SGA-1		1 [1.4]		0 [0.0]

Values are adjusted odds ratio (95% confidence interval) adjusted for days on exclusive nutritional support and count [percentage]. Refer to Additional file 1 for beta weights of potential confounders not included in the model
ENS exclusive nutritional support, GLIMPSE Global Index of Mortality Probability in the Severely ill, GOF goodness of fit derived from Hosmer-Lemeshow test, SGA Subjective Global Assessment
*Low- and high-GLIMPSE is defined as the predicted mortality risk of < 20% and > 20%, respectively
^†Interaction between energy intake and GLIMPSE categories in patients with short-term exclusive nutritional support
^‡Interaction between energy intake and GLIMPSE categories in patients with longer-term exclusive nutritional support
^§Interaction between protein intake and GLIMPSE categories in patients with shorter-term exclusive nutritional support
**Interaction between protein intake and GLIMPSE categories in patients with longer-term exclusive nutritional support
^††Comparison of 7-point SGA categories between low-GLIMPSE patients with short-term and longer-term ENS
^‡‡Comparison of 7-point SGA categories between high-GLIMPSE patients with short-term and longer-term ENS

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