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Fig. 5 | Critical Care

Fig. 5

From: Post-stroke treatment with argon attenuated brain injury, reduced brain inflammation and enhanced M2 microglia/macrophage polarization: a randomized controlled animal study

Fig. 5

Microglia/macrophage activation with ionized calcium binding adaptor molecule 1 (Iba1) immunohistochemistry in rat brain 7 days after reperfusion. Representative images of resting microglia (a, left) at the contralateral cortex, intermediately activated “Stellate” microglia (a, middle) at the ischemic boundary zone and highly activated “amoeboid” microglia/macrophages (a, right) at the ischemic core; representative images of overall microglia/macrophage activation in rat brain samples (b); positive area of Iba1 immunostaining in the affected hemisphere (c). Significance was indicated with **p < 0.01. Treatment of argon significantly suppressed the general microglia/macrophage activation (p = 0.0076). Results were represented as mean ± SD, n = 8 for tMCAO Ar group and n = 7 for tMCAO N2 group

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Critical Care

ISSN: 1364-8535