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Table 3 Cox regression analysis of risk factors associated with 180-day mortality in neurocritically ill patients (n = 50)

From: Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death

Parameters

Univariate

Multivariate

HR (95%CI)

p value

aHR (95%CI)

p value

Candidate variables

 APACHE-II

1.299 (1.008–1.674)

0.044

  

 Respiratory failure

3.853 (1.033–14.366)

0.045

  

 Intracranial hypertension

4.472 (1.115–17.938)

0.035

  

 Serum lactate

1.367 (1.042–1.793)

0.024

  

The changes of the specific taxon abundance during first week after admission (z-score)

 ΔFusobacteria

0.262 (0.097–0.708)

0.008

–

NS

 ΔFusobacteriales

0.262 (0.097–0.708)

0.008

–

NS

 ΔEnterobacteriales

1.756 (1.010–3.056)

0.046

1.920♯ (1.016–3.628)

0.044

 ΔVeillonellaceae

1.475 (1.005–2.165)

0.047

–

NS

 ΔFusobacteriaceae

0.262 (0.097–0.706)

0.008

–

NS

 ΔEnterobacteriaceae

1.756 (1.010–3.056)

0.046

1.920♯ (1.016–3.628)

0.044

  1. ♯Adjusted for APACHE-II, respiratory failure, intracranial hypertension and serum lactate
  2. HR Hazard ratio, aHR adjusted hazard ratio, 95%CI 95% confidence interval, SOFA Sequential Organ Failure Assessment, APACHE-II Acute Physiology and Chronic Health Evaluation-II, WBC white blood cell, Cr creatinine, NS not significant