Fig. 1

Heterogeneous morbidity profile in critical care patients. a Percent of patients suffering from multimorbidity progressively increases with age (average ± standard deviation). b Disease composition is non-homogenous over each age bracket but organizes into the following patterns: (1) diseases that are more prevalent increase progressively with age, (2) diseases with lower prevalence (0–3.8%), and (3) diseases with an earlier prevalence peak and lower prevalence with older population. Color code (right) represents percent prevalence. c Network discovery of disease co-occurrence shows broad range of disease associations in the critical care study cohort. Note intuitive examples such as associated cardiopulmonary conditions, diabetic nephropathy, co-occurrence of alcohol abuse, liver disease, and coagulopathy. Node size represents disease prevalence; edge width expresses relative risk for each disease pair for each disease pair; bar highlighting the multiple disease clusters in Fig 1b