Dosing regimen | PTA ≥ 80% for AUC/MIC of 200 by MIC (mg/L) | PTA ≥ 80% for fAUC/MIC of 1.3 by MIC (mg/L) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
0.031 | 0.063 | 0.12 | 0.25 | 0.5 | 0.031 | 0.063 | 0.12 | 0.25 | 0.5 | |
300 mg q8h × 4 | ✓ | ✓ | × | × | × | ✓ | ✓ | × | × | × |
400 mg q8h × 4 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | × | × |
500 mg q8h × 4 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | × | × |
600 mg q8h × 4 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | × | × |
700 mg q8h × 4 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | ✓ | × |
800 mg q8h × 4 | ✓ | ✓ | ✓ | ✓ | × | ✓ | ✓ | ✓ | ✓ | × |
300 mg q12h × 3 | ✓ | ✓ | × | × | × | ✓ | ✓ | × | × | × |
400 mg q12h × 3 | ✓ | ✓ | × | × | × | ✓ | ✓ | × | × | × |
500 mg q12h × 3 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | × | × |
600 mg q12h × 3 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | × | × |
700 mg q12h × 3 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | × | × |
800 mg q12h × 3 | ✓ | ✓ | ✓ | × | × | ✓ | ✓ | ✓ | × | × |