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Table 7 Monte-Carlo simulation predicted the probability of target attainment (PTA) for prophylaxis based on total and unbound AUC/MIC ratios of 100 and 0.65, respectively. Simulation was for albumin = 20 g/L and BMI = 24 kg/m2

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

Dosing regimen PTA ≥ 80% for AUC/MIC of 100 by MIC (mg/L) PTA ≥ 80% for fAUC/MIC of 0.65 by MIC (mg/L)
0.031 0.063 0.12 0.25 0.5 0.031 0.063 0.12 0.25 0.5
300 mg q8h × 4 × × × ×
400 mg q8h × 4 × ×
500 mg q8h × 4 × ×
600 mg q8h × 4 × ×
700 mg q8h × 4 ×
800 mg q8h × 4
300 mg q12h × 3 × × × ×
400 mg q12h × 3 × × × ×
500 mg q12h × 3 × × ×
600 mg q12h × 3 × ×
700 mg q12h × 3 × ×
800 mg q12h × 3 × ×
  1. Check mark denotes PTA ≥ 80%; x mark denotes PTA < 80%