Table 7 Monte-Carlo simulation predicted the probability of target attainment (PTA) for prophylaxis based on total and unbound AUC/MIC ratios of 100 and 0.65, respectively. Simulation was for albumin = 20 g/L and BMI = 24 kg/m²

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

Dosing regimen	PTA ≥ 80% for AUC/MIC of 100 by MIC (mg/L)					PTA ≥ 80% for fAUC/MIC of 0.65 by MIC (mg/L)
Dosing regimen	0.031	0.063	0.12	0.25	0.5	0.031	0.063	0.12	0.25	0.5
300 mg q8h × 4	✓	✓	✓	×	×	✓	✓	✓	×	×
400 mg q8h × 4	✓	✓	✓	✓	×	✓	✓	✓	✓	×
500 mg q8h × 4	✓	✓	✓	✓	×	✓	✓	✓	✓	×
600 mg q8h × 4	✓	✓	✓	✓	×	✓	✓	✓	✓	×
700 mg q8h × 4	✓	✓	✓	✓	×	✓	✓	✓	✓	✓
800 mg q8h × 4	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
300 mg q12h × 3	✓	✓	✓	×	×	✓	✓	✓	×	×
400 mg q12h × 3	✓	✓	✓	×	×	✓	✓	✓	×	×
500 mg q12h × 3	✓	✓	✓	×	×	✓	✓	✓	✓	×
600 mg q12h × 3	✓	✓	✓	✓	×	✓	✓	✓	✓	×
700 mg q12h × 3	✓	✓	✓	✓	×	✓	✓	✓	✓	×
800 mg q12h × 3	✓	✓	✓	✓	×	✓	✓	✓	✓	×

Check mark denotes PTA ≥ 80%; x mark denotes PTA < 80%

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com