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Table 5 Intravenous loading dose regimens for treatment, stratified by serum albumin concentration and body mass index, for ≥ 80% probability of achieving unbound trough concentration ≥ 0.0033 mg/L at 48 h

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

BMI (kg/m2)

Albumin (g/L)

15

25

35

45

17

500 mg q12h × 3

500 mg q12h × 3

500 mg q12h × 3

500 mg q12h × 3

400 mg q8h × 4

400 mg q8h × 4

400 mg q8h × 4

700 mg q8h × 4

24

600 mg q12h × 3

600 mg q12h × 3

600 mg q12h × 3

600 mg q12h × 3

500 mg q8h × 4

500 mg q8h × 4

500 mg q8h × 4

500 mg q8h × 4

31

800 mg q12h × 3

800 mg q12h × 3

800 mg q12h × 3

800 mg q12h × 3

700 mg q8h × 4

700 mg q8h × 4

700 mg q8h × 4

700 mg q8h × 4

38

> 800 mg q12h × 3

> 800 mg q12h × 3

> 800 mg q12h × 3

> 800 mg q12h × 3

800 mg q8h × 4

800 mg q8h × 4

800 mg q8h × 4

800 mg q8h × 4