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Table 5 Intravenous loading dose regimens for treatment, stratified by serum albumin concentration and body mass index, for ≥ 80% probability of achieving unbound trough concentration ≥ 0.0033 mg/L at 48 h

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

BMI (kg/m2) Albumin (g/L)
15 25 35 45
17 500 mg q12h × 3 500 mg q12h × 3 500 mg q12h × 3 500 mg q12h × 3
400 mg q8h × 4 400 mg q8h × 4 400 mg q8h × 4 700 mg q8h × 4
24 600 mg q12h × 3 600 mg q12h × 3 600 mg q12h × 3 600 mg q12h × 3
500 mg q8h × 4 500 mg q8h × 4 500 mg q8h × 4 500 mg q8h × 4
31 800 mg q12h × 3 800 mg q12h × 3 800 mg q12h × 3 800 mg q12h × 3
700 mg q8h × 4 700 mg q8h × 4 700 mg q8h × 4 700 mg q8h × 4
38 > 800 mg q12h × 3 > 800 mg q12h × 3 > 800 mg q12h × 3 > 800 mg q12h × 3
800 mg q8h × 4 800 mg q8h × 4 800 mg q8h × 4 800 mg q8h × 4