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Table 3 Intravenous loading dose regimens for prophylaxis, stratified by serum albumin concentration and body mass index, for ≥ 80% probability of achieving unbound trough concentration ≥ 0.0023 mg/L at 48 h

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

BMI (kg/m2) Albumin (g/L)
15 25 35 45
17 300 mg q12h × 3 300 mg q12h × 3 300 mg q12h × 3 300 mg q12h × 3
24 500 mg q12 h × 3 500 mg q12h × 3 500 mg q12h × 3 500 mg q12h × 3
400 mg q8h × 4 400 mg q8h × 4 400 mg q8h × 4 400 mg q8h × 4
31 600 mg q12h × 3 600 mg q12h × 3 600 mg q12h × 3 600 mg q12h × 3
500 mg q8h × 4 500 mg q8h × 4 500 mg q8h × 4 500 mg q8h × 4
38 700 mg q12h × 3 700 mg q12h × 3 700 mg q12h × 3 700 mg q12h × 3
600 mg q8h × 4 600 mg q8h × 4 600 mg q8h × 4 600 mg q8h × 4