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Table 2 Pharmacokinetic parameter estimates for the final covariate model

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

 

Mean

SD

CV%

Ke (h−1)

42.07

23.68

56

VƟ (l)

72.19

43.14

60

Kcp (h−1)

334.27

236.42

71

Kpc (h−1)

0.37

0.11

31

Kon (L/mg/h)

2820.35

671.99

24

Koff (h−1)

3897.40

596.46

15

  1. SD standard deviation, CV coefficient of variation, Ke elimination rate constant, VƟ typical volume of distribution of the central compartment, Kcp rate constant for distribution of unbound posaconazole from central to peripheral compartment, Kpc rate constant for distribution of unbound posaconazole from peripheral to central compartment, Kon second-order association rate constant for binding of posaconazole to albumin, Koff first-order rate constant for dissociation of posaconazole from albumin
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Critical Care

ISSN: 1364-8535