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Table 1 Characteristics of study participants

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

Characteristic n (%) or median (IQR)
Age (years) 46 (40–51)
Sex
 Male 7 (88%)
 Female 1 (12%)
Body mass index (kg/m2) 22.6 (20.2–29.7)
Weight (kg) 68 (65–82)
Serum creatinine (μmol/L) 106 (78–197)
Urinary creatinine clearance (mL/min) 74 (53–109)
Albumin (g/L) 20 (18–24)
Alanine transaminase (IU/mL) 53 (28–60)
Aspartate transaminase (IU/mL) 47 (38–130)
Alkaline phosphatase (IU/mL) 75 (63–108)
Total bilirubin (μmol/L) 11 (10–20)
APACHE II score (admission) 17 (17–24)
SOFA Score
 Day 1 5 (3–6)
 Day 2 3 (2–4)
 Patients with positive culture 4 (50%)
Organisms isolated
Candida albicans 2 (25%)
Candida dubliniensis 2 (25%)
Candida parasilosis 1 (12%)
Candida glabrata complex 1 (12%)
Candida spp. 1 (12%)
Antifungals prescribed
Fluconazole 6 (75%)
Voriconazole 2 (25%)
Caspofungin 3 (37%)
Amphotericin 1 (12%)
  1. IQR interquartile range, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA Sequential Organ Failure Assessment