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Fig. 1 | Critical Care

Fig. 1

From: Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

Fig. 1

Schematics of the final structural pharmacokinetic model. Cf(t) and Cb(t) are free and bound posaconazole concentration in the central compartment at time t, respectively. Cp(t), posaconazole concentration in the peripheral compartment at time t; ke, first-order elimination rate constant; V, volume of distribution of the central compartment; kcp, rate constant for distribution of unbound posaconazole from central to peripheral compartment; Kpc, rate constant for distribution of unbound posaconazole from peripheral to central compartment; Kon, second-order association rate constant for binding of posaconazole to albumin; Koff, first-order rate constant for dissociation of posaconazole from albumin

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Critical Care

ISSN: 1364-8535