Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study

Table 1 Baseline patient characteristics of patients in MESSI and PETROS cohorts

	MESSI cohort (n = 120)	PETROS cohort (n = 180)
Demographics
Age, years	61 (50–68)	41 (25–62)
Male sex	71 (59)	140 (78)
Race^a
White	63 (53)	76 (42)
Black	51 (43)	89 (49)
Other^b	6 (4)	15 (8)
Body mass index (kg/m²)	26.5 (22.1–32.7)	25.3 (22.7–28.5)
Medical history
Hypertension^a	70 (58)	50 (28)
Diabetes mellitus^a	45 (38)	13 (7)
Congestive heart failure^a	21 (18)	7 (4)
Chronic kidney disease^ac	20 (17)	5 (3)
Chronic lung disease^a	15 (13)	0 (0)
Chronic alcohol abuse^ad	15 (13)	10 (6)
Smoking history^ad
Never	56 (47)	66 (40)
Former	27 (23)	25 (15)
Current	19 (16)	72 (44)
Acute injury and illness
Blunt trauma mechanism	N/A	137 (76)
Injury Severity Score	N/A	25 (19–30)
Operation prior to ICU admission	N/A	74 (41)
APACHE II	29 (21–37)	17 (12–24)
Shock prior to ICU admission^ae	93 (78)	89 (50)
Crystalloid, liters^adf	3.5 (2.0–6.9)	2.5 (1.2–4.0)
Pulmonary source of sepsis	51 (43)	N/A
Transfusions (days 0 + 1)^g
Received RBC transfusion	31 (26)	108 (60)
Number of units	2 (1–2)	5 (3–9)
Received FFP transfusion	16 (13)	67 (37)
Number of units	3 (2–4)	4 (2–6)
Received platelet transfusion	18 (15)	62 (34)
Number of doses^h	2 (1–3)	2 (1–2)
Outcomes
ARDS	44 (37)	37 (21)
AKIⁱ	41 (37)	53 (30)
30-day mortality	50 (42)	17 (9)

Data are shown as n (%) for categorical variables and median (interquartile range) for continuous variables. Definition of abbreviations: ARDS acute respiratory distress syndrome, SBP systolic blood pressure, ED emergency department, ICU intensive care unit, RBC red blood cell, FFP fresh frozen plasma. ^aMissing data for PETROS cohort: race (n = 4); hypertension [4]; diabetes [3]; coronary heart disease [3]; congestive heart failure [2]; chronic kidney disease [1]; chronic lung disease [1]; chronic alcohol abuse [5]; smoking history [17]; shock prior to ICU admission [1]; crystalloid [4]. ^bIn PETROS cohort, Asian (n = 9), North American Indian/Alaskan Native (n = 2), and Unknown (n = 2); in MESSI cohort, Asian (n = 1) and unknown (n = 5). ^cIncludes patients with end-stage renal disease (MESSI n = 9, PETROS n = 1). ^dMissing data for MESSI cohort: chronic alcohol abuse (n = 19); smoking history [18]; crystalloid [2]. ^eShock defined as need for vasopressors or mean arterial pressure < 65 mmHg (MESSI) or systolic arterial pressure < 90 mmHg (PETROS). ^fAdministered during the first 24 h after ED presentation (MESSI) or prior to ICU arrival (PETROS). ^gThe calendar day of and the day after presentation. ^hEach platelet dose at our institution is roughly equivalent to 4 single-donor platelet units or 6 pooled platelet units. ⁱAKI numbers exclude patients with end-stage renal disease

ISSN: 1364-8535