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Table 1 Baseline patient characteristics of patients in MESSI and PETROS cohorts

From: Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study

  MESSI cohort (n = 120) PETROS cohort (n = 180)
Demographics
 Age, years 61 (50–68) 41 (25–62)
 Male sex 71 (59) 140 (78)
 Racea
  White 63 (53) 76 (42)
  Black 51 (43) 89 (49)
  Otherb 6 (4) 15 (8)
 Body mass index (kg/m2) 26.5 (22.1–32.7) 25.3 (22.7–28.5)
Medical history
 Hypertensiona 70 (58) 50 (28)
 Diabetes mellitusa 45 (38) 13 (7)
 Congestive heart failurea 21 (18) 7 (4)
 Chronic kidney diseaseac 20 (17) 5 (3)
 Chronic lung diseasea 15 (13) 0 (0)
 Chronic alcohol abusead 15 (13) 10 (6)
 Smoking historyad
  Never 56 (47) 66 (40)
  Former 27 (23) 25 (15)
  Current 19 (16) 72 (44)
Acute injury and illness
 Blunt trauma mechanism N/A 137 (76)
 Injury Severity Score N/A 25 (19–30)
 Operation prior to ICU admission N/A 74 (41)
 APACHE II 29 (21–37) 17 (12–24)
 Shock prior to ICU admissionae 93 (78) 89 (50)
 Crystalloid, litersadf 3.5 (2.0–6.9) 2.5 (1.2–4.0)
 Pulmonary source of sepsis 51 (43) N/A
Transfusions (days 0 + 1)g
 Received RBC transfusion 31 (26) 108 (60)
  Number of units 2 (1–2) 5 (3–9)
 Received FFP transfusion 16 (13) 67 (37)
  Number of units 3 (2–4) 4 (2–6)
 Received platelet transfusion 18 (15) 62 (34)
  Number of dosesh 2 (1–3) 2 (1–2)
Outcomes
 ARDS 44 (37) 37 (21)
 AKIi 41 (37) 53 (30)
 30-day mortality 50 (42) 17 (9)
  1. Data are shown as n (%) for categorical variables and median (interquartile range) for continuous variables. Definition of abbreviations: ARDS acute respiratory distress syndrome, SBP systolic blood pressure, ED emergency department, ICU intensive care unit, RBC red blood cell, FFP fresh frozen plasma. aMissing data for PETROS cohort: race (n = 4); hypertension [4]; diabetes [3]; coronary heart disease [3]; congestive heart failure [2]; chronic kidney disease [1]; chronic lung disease [1]; chronic alcohol abuse [5]; smoking history [17]; shock prior to ICU admission [1]; crystalloid [4]. bIn PETROS cohort, Asian (n = 9), North American Indian/Alaskan Native (n = 2), and Unknown (n = 2); in MESSI cohort, Asian (n = 1) and unknown (n = 5). cIncludes patients with end-stage renal disease (MESSI n = 9, PETROS n = 1). dMissing data for MESSI cohort: chronic alcohol abuse (n = 19); smoking history [18]; crystalloid [2]. eShock defined as need for vasopressors or mean arterial pressure < 65 mmHg (MESSI) or systolic arterial pressure < 90 mmHg (PETROS). fAdministered during the first 24 h after ED presentation (MESSI) or prior to ICU arrival (PETROS). gThe calendar day of and the day after presentation. hEach platelet dose at our institution is roughly equivalent to 4 single-donor platelet units or 6 pooled platelet units. iAKI numbers exclude patients with end-stage renal disease