Fig. 1

Adjusted probability of acute respiratory distress syndrome (ARDS) across the range of ΔRIPK3 (change from presentation to 48 h) in each cohort. Estimated probabilities (line) with 95% confidence intervals (gray shading) determined using post-estimation marginal analysis after multivariable logistic regression modeling. a MESSI cohort, probabilities adjusted for age, red blood cell transfusions on day of presentation, lung source of sepsis, and shock at presentation. b PETROS cohort, probabilities adjusted for red blood cell transfusions in the first 6 h, trauma mechanism, and injury severity score