Fig. 1

Frequency of septic shock in a cohort of patients admitted to the intensive care unit and diagnosed on admission. (a) All definitions except Sepsis-3. (b) Sepsis-3 only. The forest plots contain exact 95% confidence intervals, and specific studies are weighted using the inverse-variance method. The pooled summaries are obtained using the Freeman–Tukey double arcsine transformation and the DerSimonian–Laird method estimates between-study variance