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Table 2 Secondary outcomes

From: Albumin infusion rate and plasma volume expansion: a randomized clinical trial in postoperative patients after major surgery

Outcomes Slow infusion (n = 33) Rapid infusion (n = 31) Absolute difference/risk reduction (95%CI) P value
Hemodynamic outcomes
 Change in plasma volume over time, min ml/kg 866 ± 341 1226 ± 419 360 (169 to 550) P < 0.001
 TER, %/h 5.3 ± 3.1 5.4 ± 3.0 0.1 (− 1.6 to 1.5) P = 0.931
 ΔHR, beats/min 0 ± 12 1 ± 10 1 (− 7 to 4) P = 0.665
 ΔScvO2, % 1 ± 5 2 ± 9 1 (− 3 to 5) P = 0.682
 ΔHct, % − 4 ± 2 − 4 ± 2 0 (− 1to 1) P = 0.912
 ΔMAP, mmHg 4 ± 12 5 ± 13 1 (− 7 to 6) P = 0.830
 ΔCVP, cmH2O 2 ± 3 1 ± 3 1 (− 3 to 1) P = 0.164
 ΔAlbumin, g/l 4.9 ± 1.6 3.8 ± 1.4 1.1 (0 to 2) P = 0.017
 ΔLactate, mmol/l − 0.4 ± 0.8 − 0.3 ± 1.2 0.1 (− 0.4 to 0.6) P = 0.565
Postoperative complications
 Postoperative complications, number 8 6 2 (−2.2 to 0.5) P = 0.765
Glycocalyx components and hormones
 ΔHyaloronan, ng/mL − 2.6 (− 29.7 to 19.1) 2.8 (− 26.0 to 51.0) 16.6 (− 52.8 to 19.6) P = 0.461
 ΔSyndecan-1, ng/mL 31.1 (− 0.3 to 49.3) − 1.6 (− 17.0 to 64.4) 2.9 (− 39.1 to 44.9) P = 0.160
 ΔGlypican-4, ng/mL 1.2 ± 5.8 − 2.5 ± 7.9 3.6 (0 to 7.3) P = 0.048
 ΔCopeptin, pmol/l − 73.9 (− 140.8 to 26.9) − 59.3 (− 150.1 to 39.5) 20.6 (− 40.3 to 81.6) P = 0.785
 ΔRenin, mU/l − 14.3 (− 48.0 to − 5.3) − 29.9 (− 82.8 to − 7.6) 27.4 (− 6.2 to 60.9) P = 0.186
 ΔMR-proANP, pmol/l 20.6 (10.5 to 33.2) 47.8 (31.8 to 71.8) − 25.3 (− 40.0 to − 10.7) P < 0.001
  1. Data are presented as mean ± SD or median and IQR. Fisher’s exact test, unpaired t-test, or Mann-Whitney test was used for the analysis as appropriate
  2. Abbreviations: TER transcapillary escape rate, Δ change from baseline to 180 min after the start of infusion, HR heart rate, ScvO2 central venous oxygen saturation, Hct hematocrit, MAP mean arterial pressure, CVP central venous pressure, MR-pro-ANP mid-regional pro-atrial natriuretic peptide