Table 3 Subgroup analysis for outcomes (displayed with RR or SMD)
Outcomes | Postextubation respiratory failure (RR) | Reintubation (RR) | Respiratory rate (SMD) | PaO2 (SMD) |
|---|---|---|---|---|
Subgroup analyses | ||||
Study type | ||||
RCT study | 0.61 (0.41, 0.92) | 0.58 (0.30, 1.11) | − 1.12 (− 1.45, − 0.79) | 0.39 (− 0.02,0.79) |
Crossover study | Na | Na | − 0.35 (− 0.75, 0.04) | 0.14 (− 0.23, 0.51) |
Interaction | Na | Na | P = 0.004 | P = 0.38 |
Severity of patients | ||||
Severe populations | 0.42 (0.12, 1.52) | 0.39 (0.13, 1.19) | − 0.56 (− 1.29, 0.18) | 0.31 (0.05, 0.58) |
Non severe population | 0.72 (0.53, 0.99) | 0.81 (0.27, 2.45) | − 0.93 (− 1.36, − 0.50) | 0.35 (− 0.29, 1.00) |
Interaction | 0.42 | 0.36 | 0.39 | 0.92 |
HFNC flow | ||||
≥ 40 L/min | 0.59 (0.34, 1.05) | 0.72 (0.29, 1.83) | − 1.14 (− 1.47, − 0.81) | 0.39 (− 0.02, 0.79) |
< 40 L/min | 0.58 (0.35, 0.95) | 0.39 (0.21, 0.72) | − 0.44 (− 1.09, 0.21) | 0.10 (− 0.33, 0.52) |
Interaction | 0.94 | 0.28 | 0.06 | 0.33 |
Non-hypercapnic or not | ||||
Non-hypercapnic | 0.65 (0.44, 0.94) | 0.52 (0.29, 0.93) | − 0.16 (− 0.59, 0.26) | 0.10 (− 0.33, 0.52) |
Mixeda | 0.48 (0.18, 1.29) | 0.45 (0.12, 1.77) | − 1.07 (− 1.37, − 0.77) | 0.39 (− 0.02, 0.79) |
Interaction | 0.59 | 0.86 | 0.0007 | 0.33 |
HFNC duration | ||||
≥ 24 h | 0.52 (0.33, 0.84) | 0.48 (0.26, 0.89) | − 1.12 (− 1.45, − 0.79) | 0.58 (0.27, 0.90) |
< 24 h | 0.88 (0.58, 1.34) | 0.88 (0.11, 7.33) | − 0.35 (− 0.75, 0.04) | 0.09 (− 0.13, 0.30) |
Interaction | P = 0.10 | P = 0.59 | P = 0.004 | P = 0.01 |
Post cardiac surgery or not | ||||
Post cardiac surgery | Na | 0.96 (0.04, 24.84) | Na | Na |
Other patients | 0.62 (0.42, 0.92) | 0.55 (0.28, 1.08) | − 0.70 (− 1.16, − 0.25) | 0.30 (0.04, 0.56) |
Interaction | Na | P = 0.74 | Na | Na |