High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation: a systematic review and meta-analysis

Zhu, Youfeng; Yin, Haiyan; Zhang, Rui; Ye, Xiaoling; Wei, Jianrui

doi:10.1186/s13054-019-2465-y

Critical Care

Table 1 Basic characteristics of the included studies

From: High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation: a systematic review and meta-analysis

Study	Study type	Country	Settings	Patients	Conventional oxygen therapy group		HFNC group					Follow-up duration
Study	Study type	Country	Settings	Patients	Delivery method	Oxygen flow (L/min)	Delivery device	Humidifier	Flow rate (L/min)	FiO₂	Duration (hours)	Follow-up duration
Parke 2013 [17, 28]	Single-center, open-label RCT	New Zealand	ICU	Post-cardiac surgery	Face mask or nasal prongs	2–4	Optiflow™ system	AIRVO™	45	Adjusted by medical staff to maintain a SpO₂ > 93%	48	28 days
Maggiore 2014 [12]	Two-center, open-label RCT	Italy	ICU	Medical, Surgical-trauma	Venturi mask	Adjusted to maintain an SaO₂ 92–98%^#	Optiflow™ system	Na	50	Adjusted to maintain an SaO₂ 92–98%^#	48	48 h
Corley 2015 [19]	Single-center RCT	Australia	ICU	Post-cardiac surgery with BMI ≥ 30	Face mask or nasal cannulae	2–6	Optiflow™ system	MR850 heated humidifier	35–50	Adjusted to maintain a SpO₂ ≥ 95%	> 8	Until ICU discharge
Hernández 2016 [22]	Multicenter RCT	Spain	ICU	Medical, surgical, trauma patients with low risk of reintubation^&	Non-rebreathing facemask or nasal cannula	Adjusted to maintain SpO2 ≥ 92%	Optiflow system	N/a	> 10	Adjusted to maintain a SpO2 ≥ 92%	24	Until hospital discharge
Futier 2016 [27]	Multicenter RCT	France	ICU	Post major abdominal surgery	Face mask or nasal prongs	Adjusted to maintain SpO2 ≥ 95%	Optiflow™ system	MR850 heated humidifier	50–60	Adjusted to maintain a SpO2 ≥ 95%	< 24	Until hospital discharge
Song 2017 [18]	Single-center RCT	China	ICU	ARF patients	Air entrainment mask	0.4	PT101AZ	N/a	< 60	0.4	24	24 h
Fernandez 2017 [23]	Multicenter RCT	Spain	ICU	High risk of extubation failure with non-hypercapnic*	Face mask or nasal prongs	Adjusted to maintain SpO2 92–95%	Optifow®	N/a	40	Adjusted to maintain a SpO2 92–95%	24	Until hospital discharge
Tiruvoipati 2010 [25]	Randomized crossover trial, single center	Australia	ICU	ICU patients	Face mask	0.3–0.4	Optiflow system	N/a	30	0.3–0.4	0.5	30 min
Rittayamai 2014 [13]	Randomized crossover trial, single center	Thailand	RCU	RCU patients	Non-rebreathing mask	Adjusted to maintain SpO2 ≥ 94%	Optiflow system	N/a	35	Adjusted to maintain a SpO2 ≥ 94%	0.5	30 min
Di mussi 2018 [26]	Self-cross control study, single center	Italy	ICU	COPD	Face mask	Adjusted to maintain an SaO2 88–92%	AIRVO™ system	N/a	20–60	Adjusted to maintain an SaO2 88–92%	1	1 h

COT conventional oxygen therapy, HFNC high-flow nasal cannula, RCT randomized controlled trial, ICU intensive care unit, PaO₂ partial pressure of arterial oxygen, FiO₂ fraction of inspired oxygen, ARF acute respiratory failure, RCU respiratory care unit, COPD chronic obstructive pulmonary disease
^#In populations with compensated hypercapnia, SaO₂ was 88–95%
^&Low risk of reintubation was defined as fulfilling the following criteria: simple weaning; age < 65; heart failure was not the first reason for mechanical ventilation (MV); body mass index (BMI) < 30; Acute Physiology and Chronic Health Evaluation II score < 12; no moderate-to-severe COPD; no airway patency problems; well airway clearance ability; comorbidities< 2; and no prolonged MV
*High risk of extubation failure was defined as including at least one of the following criteria: heart failure was the first reason for MV; age > 65; non-hypercapnic moderate-to-severe COPD; Acute Physiology and Chronic Health Evaluation II score > 12; BMI > 30 kg/m²; duration of MV > 7 days; bad airway clearance ability; spontaneous breathing trial failure> 1

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ISSN: 1364-8535

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