Skip to main content

Table 1 Basic characteristics of the included studies

From: High-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients after planned extubation: a systematic review and meta-analysis

Study Study type Country Settings Patients Conventional oxygen therapy group HFNC group Follow-up duration
Delivery method Oxygen flow (L/min) Delivery device Humidifier Flow rate (L/min) FiO2 Duration (hours)
Parke 2013 [17, 28] Single-center, open-label RCT New Zealand ICU Post-cardiac surgery Face mask or nasal prongs 2–4 Optiflow™ system AIRVO™ 45 Adjusted by medical staff to maintain a SpO2 > 93% 48 28 days
Maggiore 2014 [12] Two-center, open-label RCT Italy ICU Medical, Surgical-trauma Venturi mask Adjusted to maintain an SaO2 92–98%# Optiflow™ system Na 50 Adjusted to maintain an SaO2 92–98%# 48 48 h
Corley 2015 [19] Single-center RCT Australia ICU Post-cardiac surgery with BMI ≥ 30 Face mask or nasal cannulae 2–6 Optiflow™ system MR850 heated humidifier 35–50 Adjusted to maintain a SpO2 ≥ 95% > 8 Until ICU discharge
Hernández 2016 [22] Multicenter RCT Spain ICU Medical, surgical, trauma patients with low risk of reintubation& Non-rebreathing facemask or nasal cannula Adjusted to maintain SpO2 ≥ 92% Optiflow system N/a > 10 Adjusted to maintain a SpO2 ≥ 92% 24 Until hospital discharge
Futier 2016 [27] Multicenter RCT France ICU Post major abdominal surgery Face mask or nasal prongs Adjusted to maintain SpO2 ≥ 95% Optiflow™ system MR850 heated humidifier 50–60 Adjusted to maintain a SpO2 ≥ 95% < 24 Until hospital discharge
Song 2017 [18] Single-center RCT China ICU ARF patients Air entrainment mask 0.4 PT101AZ N/a < 60 0.4 24 24 h
Fernandez 2017 [23] Multicenter RCT Spain ICU High risk of extubation failure with non-hypercapnic* Face mask or nasal prongs Adjusted to maintain SpO2 92–95% Optifow® N/a 40 Adjusted to maintain a SpO2 92–95% 24 Until hospital discharge
Tiruvoipati 2010 [25] Randomized crossover trial, single center Australia ICU ICU patients Face mask 0.3–0.4 Optiflow system N/a 30 0.3–0.4 0.5 30 min
Rittayamai 2014 [13] Randomized crossover trial, single center Thailand RCU RCU patients Non-rebreathing mask Adjusted to maintain SpO2 ≥ 94% Optiflow system N/a 35 Adjusted to maintain a SpO2 ≥ 94% 0.5 30 min
Di mussi 2018 [26] Self-cross control study, single center Italy ICU COPD Face mask Adjusted to maintain an SaO2 88–92% AIRVO™ system N/a 20–60 Adjusted to maintain an SaO2 88–92% 1 1 h
  1. COT conventional oxygen therapy, HFNC high-flow nasal cannula, RCT randomized controlled trial, ICU intensive care unit, PaO2 partial pressure of arterial oxygen, FiO2 fraction of inspired oxygen, ARF acute respiratory failure, RCU respiratory care unit, COPD chronic obstructive pulmonary disease
  2. #In populations with compensated hypercapnia, SaO2 was 88–95%
  3. &Low risk of reintubation was defined as fulfilling the following criteria: simple weaning; age < 65; heart failure was not the first reason for mechanical ventilation (MV); body mass index (BMI) < 30; Acute Physiology and Chronic Health Evaluation II score < 12; no moderate-to-severe COPD; no airway patency problems; well airway clearance ability; comorbidities< 2; and no prolonged MV
  4. *High risk of extubation failure was defined as including at least one of the following criteria: heart failure was the first reason for MV; age > 65; non-hypercapnic moderate-to-severe COPD; Acute Physiology and Chronic Health Evaluation II score > 12; BMI > 30 kg/m2; duration of MV > 7 days; bad airway clearance ability; spontaneous breathing trial failure> 1