Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients

Table 3 Hospital mortality by early change in daily SOFA scores

Change in SOFA scores¹	Number of patients	Hospital mortality, n (%)
Change in SOFA scores¹	Number of patients	Increase in SOFA score	No increase in SOFA score	p value⁴
Day 1 to day 2	15,736	1014 (33.0)	2532 (20.0)	< 0.001
Day 1 to day 3	12,650	870 (35.2)	1964 (19.3)	< 0.001
Day 1 to day 4	10,206	698 (37.8)	1678 (20.1)	< 0.001
Day 1 to day 5	8326	586 (40.5)	1424 (20.7)	< 0.001
Day 2 to day 3	12,648	913 (29.9)	1920 (20.0)	< 0.001
Day 2 to day 4	10,203	794 (34.2)	1581 (20.1)	< 0.001
Day 2 to day 5	8324	670 (38.1)	1339 (20.4)	< 0.001
Day 3 to day 4	10,205	771 (32.4)	1605 (20.5)	< 0.001
Day 3 to day 5	8326	652 (35.1)	1358 (21.0)	< 0.001
Day 4 to day 5	8326	631 (31.8)	1379 (21.8)	< 0.001
Day 1 to any day during ICU stay (any increase)	15,740	1835 (34.2)	1712 (16.5)	< 0.001
Day 1 to any day during ICU stay (≥ 2 point increase)²	15,740	1410 (40.3)	2137 (17.5)	< 0.001
Day 1 to any day during ICU stay (≥ 3 point increase)³	15,740	1082 (47.4)	2465 (18.3)	< 0.001

SOFA Sequential Organ Failure Assessment
¹Based on patients who had SOFA scores on both days
²Comparison is patients with an increase in SOFA score ≥ 2 vs. patients with an increase < 2 points or a decrease
³Comparison is patients with an increase in SOFA score ≥ 3 vs. patients with an increase < 3 points or a decrease
⁴p value is based on a chi-squared test

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