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Table 2 Metabolites found to discriminate between SSS and SSN at H0

From: Nuclear magnetic resonance-based serum metabolomic analysis reveals different disease evolution profiles between septic shock survivors and non-survivors

Peaks

Assignment

VIP

Correlation

Adj P

FDR

1.06d

3-Hydroxyisobutyrate

3.06

0.52

0.0001

0.0001

5.79s

Urea

2.64

0.45

0.002

0.003

7.31m 7.36m

Phenylalanine

2.64

0.44

0.01

0.01

2.12m, 2.32m

Glutamate

2.6

0.44

0.02

0.02

2.43m

Glutamine

2.55

0.43

0.03

0.01

3.03s

Creatinine

2.43

0.41

0.03

0.04

1.32d 4.11q

Lactate

2.38

0.4

0.02

0.04

2.14s

Methionine

2.17

0.37

0.06

0.05

1.46d

Alanine

2.12

0.26

0.07

0.08

6.88d 7.18d

Tyrosine

2.02

0.34

0.03

0.04

2.36s

Pyruvate

2.01

0.34

0.03

0.01

2.52d 2.62d

Citrate

1.94

0.33

0.03

0.04

1.7m

Lysine

1.91

0.27

0.09

0.08

6.52s

Fumarate

1.9

0.32

0.04

0.05

7.67s

1-Methylhistidine

1.66

0.28

0.07

0.06

2.03s

Glycoprotein (N-acetyl)

1.64

− 0.28

0.08

0.03

1.91s

Acetate

1.56

0.25

0.09

0.10

1.16d

Isopropanol

1.53

0.26

0.09

0.03

  1. Chemical shifts for the assigned metabolites are shown in the peak column. The superscripts for the peaks represent the multiplicity of the peaks. s, singlet; d, doublet; t, triplet; q, quadruplet; m, multiplet. A positive correlation indicates an increased level of the metabolite in the non-survivor while negative correlation indicates a decreased level of the metabolite. The threshold of FDR was set at 0.1. Similar expressions are also applied for Tables 3 and 4
  2. Adj P P values that are calculated by Student’s T test are adjusted with Bonferroni correction, FDR false discovery rate