Table 1 Patient characteristics
ACEi/ARB + (N = 45) | ACEi/ARB - (N = 303) | p | |
|---|---|---|---|
Characteristic at ICU admission | |||
Age—years | 64.4 ± 15.1 | 63.1 ± 14.7 | 0.6 |
Male sex—no. (%) | 32 (71) | 193 (63) | 0.3 |
Weight—kg | 85.8 ± 23.7 | 82.4 ± 20.5 | 0.3 |
Main reason for ICU admission—no. (%) | |||
Medical | 37 (82) | 263 (87) | |
Surgical, emergency | 5 (11) | 66 (22) | |
Surgical, scheduled | 3 (7) | 19 (6) | |
Serum creatinine before ICU admission | 92.0 ± 24.7 | 83.4 ± 24.0 | 0.03 |
Coexisting condition—no. (%) | |||
Chronic renal failure | 6 (13) | 26 (9) | 0.3 |
Hypertension | 28 (62) | 152 (50) | 0.1 |
Diabetes mellitus | 3 (7) | 31 (10) | 0.67 |
Congestive heart failure | 6 (13) | 17 (6) | 0.05 |
Ischemic heart disease | 8 (18) | 26 (9) | 0.05 |
SAPS III at ICU admission | 63.0 ± 14.0 | 68.3 ± 14.3 | 0.02 |
Septic shock—no. (%) | 26 (58) | 128 (42) | 0.05 |
Biological characteristics | |||
Serum creatinine—µmol/L | 203.9 (133.1) | 219.6 (136.9) | 0.47 |
Blood urea nitrogen—mmol/L | 13.0 (8.4) | 14.4 (9.3) | 0.34 |
Serum potassium—mmol/L | 4.1 (0.8) | 4.3 (0.9) | 0.37 |
Serum bicarbonate—mmol/L | 19.9 (5.0) | 18.7 (5.7) | 0.17 |
Characteristic of ICU stay | |||
Physiological support during ICU stay—no. (%) | |||
Invasive mechanical ventilation | 41 (91) | 260 (86) | 0.33 |
Vasopressor support (epinephrine or norepinephrine) | 31 (69) | 257 (85) | 0.008 |
Number of patients who received RRT—no. (%) | 28 (62) | 211 (70) | 0.32 |
Ventilator duration—median (IQR) | 5 (5–13) | 5 (4–10) | 0.40 |
Vasopressor-free days—median (IQR) | 3 (2–5) | 4 (2–7) | 0.11 |
Length of ICU stay—median (IQR) | 18 (11–20) | 15 (8–22) | 0.35 |
RRT dependence—no. (%) | |||
At day 28 | 4 (9) | 27 (9) | 0.99 |
At day 60 | 1 (2) | 9 (3) | 0.77 |
Mortality—no. (%[95% CI]) | |||
At day 60 | 6 (13) | 39 (12) | 0.73 |
Creatinine at ICU discharge | 183.6 ± 136.4 | 177.9 ± 150.1 | 0.81 |