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Table 2 Entry criteria of extracorporeal support trials

From: Extracorporeal gas exchange: when to start and how to end?

Study Patients enrolled Inclusion criteria
NIH adult ECMO trial
Zapol et al. 1979, JAMA
90 Severe ARF:
-PaO2 < 50 mmHg for at least 2 h despite 100% FIO2 and 5 cmH2O of PEEP (fast entry)
-PaO2 < 50 mmHg for at least 12 h despite 60% FIO2 and 5 cmH2O of PEEP or a Qs/Qt > 30% with 100% of FIO2 and 5 cmH2O PEEP
PCIRV vs ECCO2R
Morris, 1994, Am J Respir Crit Care Med
40 -ARDS (defined as P(a/A)O2 < 0.2, bilateral chest radiographic infiltrates, total compliance < 50 ml/cmH2O, wedge pressure < 15 mmHg and no signs of heart failure)
-ECMO criteria:
- PaO2 < 50 mmHg for at least 2 h despite 100% FIO2 and 5 cmH2O of PEEP (fast entry)
- PaO2 < 50 mmHg or Qs/Qt > 30% for at least 12 h despite 60% FIO2 and 5 cmH2O of PEEP, in a > 48 h ICU patients (slow entry)
CESAR trial
Peek et al. 2009, Lancet
180 -Severe but potentially reversible respiratory failure
(Murray score > 2.5 or hypercapnia with arterial pH < 7.2)
-Age 18–65
-Ventilation/high FIO2 < 7 days
-No cranial bleeding
-No contraindication to heparin
-No contraindication to continuation of the active treatment
EOLIA trial
Combes et al. 2018, NEJM
249 -ARDS
-Mechanical ventilation < 7 days
-With (despite ventilator optimization):
• PaO2/FIO2 < 50 for at least 3 h
• PaO2/FIO2 < 80 for at least 6 h
• Arterial pH < 7 .25 with PaCO2 > 60 mmHg for at least 6 h