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Fig. 3 | Critical Care

Fig. 3

From: Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury

Fig. 3

Trends over time of the Neurological Pupil index (NPi) during elevated intracranial pressure (ICP) treated with osmotherapy (mannitol or hypertonic saline bolus). Line graphs illustrating trends over time of the NPi (blue line) during 15 episodes of elevated ICP (gray line). Data are mean ± standard deviation of a total of 50 paired ICP-NPi measurements; **p < 0.001 for pairwise comparisons of baseline ICP and NPi values (start of osmotherapy [red arrow]) with Ti (≈ − 4 h), Tii (≈ − 2 h), ICP min, and NPi max, respectively (time 0)

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