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Table 2 Pharmacokinetic parameters of ceftolozane and tazobactam

From: Optimizing ceftolozane-tazobactam dosage in critically ill patients during continuous venovenous hemodiafiltration

ParameterCeftolozaneTazobactam
Pre-filterPost-filterPre-filterPost-filter
Clearance (L/h)2.15.46.417.4
Volume of distribution (L)53.997.5108.9194.2
Half-life (h)17.912.611.97.8
AUC (h mg/L)96037315757.6
Maximum concentration (mg/L)99533714.5
Minimum concentration (mg/L)55.925.811.45.1
  1. AUC area under the concentration-time curve