Table 2 Pharmacokinetic parameters of ceftolozane and tazobactam
Parameter | Ceftolozane | Tazobactam | ||
|---|---|---|---|---|
Pre-filter | Post-filter | Pre-filter | Post-filter | |
Clearance (L/h) | 2.1 | 5.4 | 6.4 | 17.4 |
Volume of distribution (L) | 53.9 | 97.5 | 108.9 | 194.2 |
Half-life (h) | 17.9 | 12.6 | 11.9 | 7.8 |
AUC (h mg/L) | 960 | 373 | 157 | 57.6 |
Maximum concentration (mg/L) | 99 | 53 | 37 | 14.5 |
Minimum concentration (mg/L) | 55.9 | 25.8 | 11.4 | 5.1 |