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Table 1 Concentrations of ceftolozane and tazobactam in pre-filter and post-filter plasma samples obtained after the fourth dose of 2 g/1 g ceftolozane-tazobactam administered as intravenous 1-h infusion

From: Optimizing ceftolozane-tazobactam dosage in critically ill patients during continuous venovenous hemodiafiltration

Sampling timeCeftolozane (mg/L)Tazobactam (mg/L)
0 h (pre dose)41.920.710.65.8
1.5 h post dose89.145.228.312.2
2 h post dose80.338.421.610.3
2.5 h post dose77.
3 h post dose73.834.716.38.2
5 h post dose66.630.614.27.4
7 h post dose60.228.712.76.0
8 h post dose55.825.811.45.1