Table 1 Concentrations of ceftolozane and tazobactam in pre-filter and post-filter plasma samples obtained after the fourth dose of 2 g/1 g ceftolozane-tazobactam administered as intravenous 1-h infusion
Sampling time | Ceftolozane (mg/L) | Tazobactam (mg/L) | ||
|---|---|---|---|---|
Pre-filter | Post-filter | Pre-filter | Post-filter | |
0 h (pre dose) | 41.9 | 20.7 | 10.6 | 5.8 |
1.5 h post dose | 89.1 | 45.2 | 28.3 | 12.2 |
2 h post dose | 80.3 | 38.4 | 21.6 | 10.3 |
2.5 h post dose | 77.1 | 36.1 | 19.0 | 9.0 |
3 h post dose | 73.8 | 34.7 | 16.3 | 8.2 |
5 h post dose | 66.6 | 30.6 | 14.2 | 7.4 |
7 h post dose | 60.2 | 28.7 | 12.7 | 6.0 |
8 h post dose | 55.8 | 25.8 | 11.4 | 5.1 |