Culture-negative sepsis | Culture-positive sepsis | ||||||
---|---|---|---|---|---|---|---|
Control group | Intervention group | Total | Control group | Intervention group | Total | p (Total CNS vs. CPS) | |
n | 612 | 914 | 1526 | 520 | 613 | 1133 | |
Number of organ systems affected (median [IQR]) | 1 [0, 1] | 1 [0, 1] | 1 [0, 1] | 1 [0, 2] | 1 [0, 2] | 1 [0, 2] | < 0.001 |
Cardiovascular dysfunction (n (%)) | 51 (8.5) | 84 (9.3) | 135 (9) | 78 (15.2) | 128 (21.2) | 206 (18.9) | < 0.001 |
Respiratory dysfunction (n (%)) | 215 (35.7) | 307 (33.9) | 522 (34.6) | 163 (31.6) | 230 (38) | 393 (35) | 0.849 |
Hematological dysfunction (n (%)) | 9 (1.5) | 12 (1.3) | 21 (1.4) | 6 (1.2) | 13 (2.2) | 19 (1.7) | 0.644 |
Renal dysfunction (n (%)) | 29 (4.8) | 41 (4.5) | 70 (4.7) | 50 (9.7) | 77 (12.7) | 127 (11.3) | < 0.001 |
Hepatic dysfunction (n (%)) | 13 (2.2) | 11 (1.2) | 24 (1.6) | 28 (5.4) | 29 (4.8) | 57 (5.1) | < 0.001 |
CNS dysfunction (n (%)) | 110 (18.3) | 177 (19.6) | 287 (19.1) | 128 (24.8) | 161 (26.7) | 289 (25.8) | < 0.001 |
Gastro-intestinal dysfunction (n (%)) | 2 (0.3) | 5 (0.6) | 7 (0.5) | 2 (0.4) | 3 (0.5) | 5 (0.4) | 1.000 |
Metabolic dysfunction (n (%)) | 98 (16.3) | 137 (15.1) | 235 (15.6) | 151 (29.2) | 166 (27.3) | 317 (28.2) | < 0.001 |