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Table 4 Organ dysfunction in culture-negative and culture-positive patients

From: An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial

 

Culture-negative sepsis

Culture-positive sepsis

 

Control group

Intervention group

Total

Control group

Intervention group

Total

p (Total CNS vs. CPS)

n

612

914

1526

520

613

1133

 

Number of organ systems affected (median [IQR])

1 [0, 1]

1 [0, 1]

1 [0, 1]

1 [0, 2]

1 [0, 2]

1 [0, 2]

< 0.001

Cardiovascular dysfunction (n (%))

51 (8.5)

84 (9.3)

135 (9)

78 (15.2)

128 (21.2)

206 (18.9)

< 0.001

Respiratory dysfunction (n (%))

215 (35.7)

307 (33.9)

522 (34.6)

163 (31.6)

230 (38)

393 (35)

0.849

Hematological dysfunction (n (%))

9 (1.5)

12 (1.3)

21 (1.4)

6 (1.2)

13 (2.2)

19 (1.7)

0.644

Renal dysfunction (n (%))

29 (4.8)

41 (4.5)

70 (4.7)

50 (9.7)

77 (12.7)

127 (11.3)

< 0.001

Hepatic dysfunction (n (%))

13 (2.2)

11 (1.2)

24 (1.6)

28 (5.4)

29 (4.8)

57 (5.1)

< 0.001

CNS dysfunction (n (%))

110 (18.3)

177 (19.6)

287 (19.1)

128 (24.8)

161 (26.7)

289 (25.8)

< 0.001

Gastro-intestinal dysfunction (n (%))

2 (0.3)

5 (0.6)

7 (0.5)

2 (0.4)

3 (0.5)

5 (0.4)

1.000

Metabolic dysfunction (n (%))

98 (16.3)

137 (15.1)

235 (15.6)

151 (29.2)

166 (27.3)

317 (28.2)

< 0.001

  1. CNS central nervous system or culture-negative sepsis, CPS culture-positive sepsis