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Table 4 Organ dysfunction in culture-negative and culture-positive patients

From: An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial

  Culture-negative sepsis Culture-positive sepsis  
Control group Intervention group Total Control group Intervention group Total p (Total CNS vs. CPS)
n 612 914 1526 520 613 1133  
Number of organ systems affected (median [IQR]) 1 [0, 1] 1 [0, 1] 1 [0, 1] 1 [0, 2] 1 [0, 2] 1 [0, 2] < 0.001
Cardiovascular dysfunction (n (%)) 51 (8.5) 84 (9.3) 135 (9) 78 (15.2) 128 (21.2) 206 (18.9) < 0.001
Respiratory dysfunction (n (%)) 215 (35.7) 307 (33.9) 522 (34.6) 163 (31.6) 230 (38) 393 (35) 0.849
Hematological dysfunction (n (%)) 9 (1.5) 12 (1.3) 21 (1.4) 6 (1.2) 13 (2.2) 19 (1.7) 0.644
Renal dysfunction (n (%)) 29 (4.8) 41 (4.5) 70 (4.7) 50 (9.7) 77 (12.7) 127 (11.3) < 0.001
Hepatic dysfunction (n (%)) 13 (2.2) 11 (1.2) 24 (1.6) 28 (5.4) 29 (4.8) 57 (5.1) < 0.001
CNS dysfunction (n (%)) 110 (18.3) 177 (19.6) 287 (19.1) 128 (24.8) 161 (26.7) 289 (25.8) < 0.001
Gastro-intestinal dysfunction (n (%)) 2 (0.3) 5 (0.6) 7 (0.5) 2 (0.4) 3 (0.5) 5 (0.4) 1.000
Metabolic dysfunction (n (%)) 98 (16.3) 137 (15.1) 235 (15.6) 151 (29.2) 166 (27.3) 317 (28.2) < 0.001
  1. CNS central nervous system or culture-negative sepsis, CPS culture-positive sepsis