From: Influenza and associated co-infections in critically ill immunosuppressed patients
Variables | No infection (n = 638) | Infection other than influenza (n = 820) | Influenza alone (n = 95) | Influenza & co-infection (n = 58) | P valuea |
---|---|---|---|---|---|
At day 1 | |||||
Maximum respiratory rate (breaths/min) | 30 [24–36] | 31 [25–37] | 32 [28–36] | 32 [26–38] | 0.01 |
Liters/min O2 | 7 [3–15] | 8 [5–15] | 10 [4–15] | 15 [2–15] | 0.04 |
FiO2 | 50 [40–70] | 50 [40–80] | 50 [50–72] | 59 [51–75] | 0.03 |
PaO2/FiO2 ratio | 173 [115–215] | 110 [79–173] | 113 [110–204] | 127 [87–170] | < 0.001 |
ARDS at day 1 | 481 (75) | 737 (90) | 92 (97) | 57 (98) | < 0.001 |
SOFA at ICU admission | 6 [4–9] | 7 [4–11] | 7 [4–10] | 8 [6–10] | < 0.001 |
Respiratory SOFA = 0 | 103 (17) | 94 (12) | 9 (10) | 1 (2) | < 0.001 |
Cardiovascular SOFA = 0 | 334 (53) | 341 (42) | 34 (37) | 25 (43) | < 0.001 |
Outcome | |||||
Intubation during the ICU stay | 357 (56) | 57 (60) | 530 (65) | 47 (81) | < 0.001 |
Shock | 171 (27) | 429 (52) | 47 (49) | 32 (36) | < 0.001 |
Renal replacement therapy | 93 (15) | 140 (17) | 17 (17) | 17 (29) | 0.04 |
Steroidsb | 187 (33) | 272 (36) | 27 (31) | 27 (49) | 0.09 |
ICU-acquired pneumonia | 47 (7) | 96 (12) | 14 (15) | 6 (10) | 0.01 |
ICU length of stay (days) | 5 [2–10] | 7 [3–15] | 8 [4–21] | 10.5 [5–20] | < 0.001 |
ICU mortality | 165 (26) | 302 (37) | 31 (33) | 24 (41) | < 0.001 |
Hospital mortality | 251 (41) | 365 (46) | 36 (38) | 30 (52) | 0.09 |
Day 90 mortality | 291 (45) | 410 (50) | 38 (40) | 32 (55) | 0.06 |