Table 1 Influenza infection status and baseline characteristics at ICU admission
From: Influenza and associated co-infections in critically ill immunosuppressed patients
Baseline characteristics | No infection (n = 638) | Infection other than influenza (n = 820) | Influenza alone (n = 95) | Influenza co-infection (n = 58) | P valueb |
|---|---|---|---|---|---|
Age (years), median [IQR] | 63 [54–71] | 63 [55–71] | 65 [54–72] | 64 [52–70] | 0.80 |
Gender, male | 351 (55) | 512 (63) | 59 (63) | 32 (56) | 0.04 |
Obesitya | 108 (17) | 151 (18) | 21 (22) | 12 (21) | 0.21 |
Underlying disease | |||||
Hematological disease | 311 (49) | 436 (53) | 60 (63) | 30 (51) | 0.05 |
Solid tumor | 252 (39) | 285 (35) | 18 (19) | 12 (21) | < 0.001 |
Solid organ transplantation | 51 (9) | 75 (10) | 7 (8) | 9 (16) | 0.4 |
Systemic disease or other ID | 102 (16) | 133 (16) | 25 (26) | 18 (31) | 0.002 |
Disease status at ICU admission | |||||
Newly diagnosed | 161 (36) | 154 (27) | 12 (17) | 7 (20) | 0.0004 |
Remission | 67 (15) | 82 (14) | 15 (21) | 8 (23) | |
No remission | 62 (14) | 68 (12) | 3 (4) | 6 (17) | |
Allogeneic stem cell transplant | 56 (9) | 82 (10) | 9 (9) | 5 (9) | 0.03 |
ECOGc ≥ 2 (severely disabled or bedridden) | 210 (33) | 299 (36) | 36 (38) | 23 (40) | 0.15 |
Comorbidities | |||||
Cardiac | 141 (24) | 167 (22) | 16 (18) | 15 (27) | 0.43 |
COPD | 103 (17) | 123 (15) | 14 (15) | 7 (12) | 0.80 |
Kidney | 88 (14) | 117 (15) | 16 (18) | 10 (17) | 0.75 |
Diabetes | 108 (17) | 161 (20) | 21 (22) | 14 (25) | 0.30 |
Alcohol use disorder | 63 (10) | 76 (10) | 5 (5) | 4 (7) | 0.48 |
Tobacco use | 199 (33) | 228 (29) | 21 (23) | 12 (21) | 0.08 |
Duration of symptoms before ICU admission (days), median [IQR] | 1 [0–4] | 1 [0–3] | 2 [1–7] | 1.5 [1–4] | < 0.001 |
Admission from emergency department | 208 (33) | 256 (32) | 41 (43) | 19 (33) | 0.17 |
Neutropenia at admission | 66 (11) | 153 (20) | 20 (21) | 12 (21) | < 0.001 |