Primary endpoint | Ringer’s acetate (n = 75), median (IQR) | Ringer’s lactate (n = 73), median (IQR) | p value |
---|---|---|---|
Average rate of inopressors (norepinephrine and epinephrine) [μg/kg/h] until hemodynamic stabilization | 2.1 (0.5–8.1) | 1.7 (0.7–8.2) | 0. 989 |
Secondary endpoints—vasoactive medication | |||
Average rate of norepinephrine [μg/kg/h] until hemodynamic stabilization | 1.8 (0.5–6.7) | 1.5 (0.6–4.7) | 0.672 |
Average rate of epinephrine [μg/kg/h]§ per hour on epinephrine | 0.2 (0.1–9.3) | 4.5 (0.4–33.0) | 0.047 |
Average rate of inopressors (norepinephrine and epinephrine) [μg/kg/h] per hour on inopressors | 4.1 (1.0–11.8) | 3.7 (1.6–12.1) | 0.959 |
Average rate of norepinephrine [μg/kg/h]# per hour on norepinephrine | 4.1 (1.1–11.7) | 3.4 (1.5–9.5) | 0.907 |
Average rate of epinephrine [μg/kg/h]§ per hour on epinephrine | 0.2 (0.1–9.3) | 4.5 (0.4–33.0) | 0.047 |
Cumulative dose of inopressors [μg/kg] | 22 (5–83) | 20 (7–114) | 0.928 |
Cumulative dose of norepinephrine [μg/kg] | 19 (5–71) | 16 (6–61) | 0.726 |
Cumulative dose of epinephrine [μg/kg] | 22 (5–83) | 20 (7–114) | 0.928 |
Time on inopressors [h]° | 4.8 (4.1–10.7) | 6.1 (4.0–10.6) | 0.505 |
Time on norepinephrine [h]#° | 4.8 (4.1–6.4) | 4.5 (3.7–7.4) | 0.836 |
Time on epinephrine [h]*° | 0.0 (0.0–0.0) | 0.0 (0.0–3.4) | 0.209 |
Cumulative dose of inodilators, ICU [μg] | 0 (0.0–0.0) | 0 (0.0–0.0) | 0.375 |
Time on inodilators, ICU [min] | 0 (0.0–0.0) | 0 (0.0–0.0) | 0.386 |
Cumulative dose of vasodilators [mg] | 0 (0.0–2.8) | 0 (0.0–4.2) | 0.844 |
Time on vasodilators, ICU [h] | 0 (0.0–1.7) | 0 (0.0–6.4) | 0.726 |
Secondary endpoints—fluids | |||
Total amount of study fluid received (mL) | 6677 (5325–8479) | 6104 (4769–7855) | 0.272 |
Total amount of fluid received other than study fluid during study period (mL) | 0 (0–0) | 0 (0–0) | 0.976 |
Total amount of fluid received after initial hemodynamic stabilization until ICU discharge (mL) | 289 (104–972) | 255 (121–631) | 0.711 |
Total amount of fluid received from the start of anesthesia to ICU discharge (mL) | 7189 (5622–9120) | 6644 (5400–8379) | 0.234 |