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Table 2 Low MR-proADM concentrations resulted in an absence of ICU admission or 28-day mortality, despite lower antibiotic administration rates and a significantly longer time to administration, irrespective of corresponding PCT concentration

From: Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department

Patient subgroups MR-proADM concentration
< 1.27 (nmol/L) ≥ 1.27 (nmol/L)
Subgroup 1: PCT concentration: < 0.25 μg/L (N = 106)
 Patients (N) 65 41
 Antibiotic administration (N, %) 35 (53.8%) 34 (82.9%)
 Time to antibiotic administration (min) (median, Q1-Q3) 127 [45.0–220] 42 [25.8–116]
 Composite of 28-day mortality and ICU admission (N, %) 0 (0.0%) 7 (17.1%)
Subgroup 2: PCT concentration: ≥ 0.25 and < 0.50 μg/L (N = 24)
 Patients (N) 8 16
 Antibiotic administration (N, %) 7 (87.5%) 15 (93.8%)
 Time to antibiotic administration (min) (median, Q1–Q3) 165 [88–305] 50 [19.3–186]
 Composite of 28-day mortality and ICU admission (N, %) 0 (0.0%) 1 (6.3%)
Subgroup 3: PCT concentration: ≥ 0.50 μg/L (N = 83)
 Patients (N) 21 62
 Antibiotic administration (N, %) 15 (71.4%) 59 (95.2%)
 Time to antibiotic administration (min) (median, Q1–Q3) 131 [92.8–166] 45 [26–136.5]
 Composite of 28-day mortality and ICU admission (N, %) 0 (0.0%) 15 (24.2%)
  1. MR-proADM mid-regional proadrenomedullin, N number, PCT procalcitonin, Q quartile