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Table 1 Univariate and Multivariate analyses found that MR-proADM had the strongest correlation with the requirement for antibiotic administration during ED treatment

From: Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department

Biomarker

Patient population (N)

Antibiotic administration (N)

p value

C index

Univariate OR [95% CI]

Multivariate OR [95% CI]

MR-proADM

213

164

< 0.001

0.76

3.1 [1.9–4.9]

3.3 [1.9–5.9]

PCT

213

164

< 0.001

0.74

2.7 [1.7–4.3]

2.7 [1.7–4.5]

CRP

207

159

< 0.001

0.68

1.8 [1.3–2.5]

1.9 [1.4–2.8]

Lactate

204

158

0.002

0.66

1.8 [1.2–2.6]

1.6 [1.1–2.5]

  1. Age, cardiovascular, neurological, renal and malignancy comorbidities were used as adjusting variables within the multivariate regression analysis, as previously outlined [4]. Univariate and multivariate odds ratios were expressed per 1 SD increment of the log-transformed value for each respective biomarker. CI confidence interval, CRP C-reactive protein, DF degrees of freedom, MR-proADM mid-regional proadrenomedullin, N number, OR odds ratio, PCT procalcitonin
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Critical Care

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