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Table 1 Univariate and Multivariate analyses found that MR-proADM had the strongest correlation with the requirement for antibiotic administration during ED treatment

From: Biomarkers to guide antibiotic timing and administration in infected patients presenting to the emergency department

Biomarker Patient population (N) Antibiotic administration (N) p value C index Univariate OR [95% CI] Multivariate OR [95% CI]
MR-proADM 213 164 < 0.001 0.76 3.1 [1.9–4.9] 3.3 [1.9–5.9]
PCT 213 164 < 0.001 0.74 2.7 [1.7–4.3] 2.7 [1.7–4.5]
CRP 207 159 < 0.001 0.68 1.8 [1.3–2.5] 1.9 [1.4–2.8]
Lactate 204 158 0.002 0.66 1.8 [1.2–2.6] 1.6 [1.1–2.5]
  1. Age, cardiovascular, neurological, renal and malignancy comorbidities were used as adjusting variables within the multivariate regression analysis, as previously outlined [4]. Univariate and multivariate odds ratios were expressed per 1 SD increment of the log-transformed value for each respective biomarker. CI confidence interval, CRP C-reactive protein, DF degrees of freedom, MR-proADM mid-regional proadrenomedullin, N number, OR odds ratio, PCT procalcitonin