Table 3 Responder vs. non-responder subgroup analysis: cardiovascular effects of resuscitation

MAP > 65 mmHg

Variable

Responders

Not responders

Responders

Not responders

Responders

Not responders

Responders

Not responders

 Patients

35

20

12

11

6

2

 SAP

85 ± 21

74 ± 18

121 ± 30*

95 ± 27*

138 ± 28*

100 ± 28*

124 ± 24

102 ± 25

 DAP

43 ± 10

48 ± 7

44 ± 16

43 ± 12*

35 ± 13*

35 ± 16*

43 ± 11*

31 ± 15

 MAP

57 ± 3

57 ± 3

70 ± 3*

60 ± 2*

70 ± 2*

57 ± 2*

70 ± 2*

60 ± 6

 PPV

16.8 ± 1.1

13.7 ± 2.1

11.3 ± 1.3*

11.8 ± 1.1*

10.7 ± 1.1*

11.0 ± 0.9*

9.6 ± 3.5

6.3 ± 5.3

 CI

2.09 ± 0.11

2.10 ± 0.11

2.59 ± 0.17*

2.47 ± 0.17*

2.60 ± 0.19*

2.39 ± 0.26

2.92 ± 0.04*

2.20 ± 0.31

 HR

112 ± 8

115 ± 6

88 ± 8*

108 ± 8*

92 ± 5*

114 ± 8

93 ± 6*

115 ± 7

 SV

34.8 ± 5.6

34.2 ± 3.8

54.9 ± 9.3*

42.9 ± 6.5*

54.1 ± 4.7*

37.5 ± 5.4

56.4 ± 8.0*

32.8 ± 6.2

 SVV

17.2 ± 1.9

20.7 ± 3.4

11.6 ± 1.8*

15.9 ± 4.3*

11.1 ± 1.7*

11.0 ± 3.2*

11.0 ± 2.0

11.0 ± 1.4

 Ea_dyn

1.00 ± 0.13

0.67 ± 0.14

0.99 ± 0.15

0.80 ± 1.75*

0.98 ± 0.14

1.08 ± 0.38*

0.88 ± 0.44

0.60 ± 0.57

 Ees

1.43 ± 0.39

1.40 ± 0.28

1.73 ± 0.31*

1.50 ± 0.30*

1.81 ± 0.25*

1.19 ± 0.19*

1.70 ± 0.09*

1.40 ± 0.71

 Ea

2.20 ± 0.38

1.96 ± 0.42

1.98 ± 0.34*

1.97 ± 0.37

2.24 ± 0.37*

2.44 ± 0.44*

1.93 ± 0.12*

2.35 ± 0.63

 Ea/Ees

1.62 ± 0.43

1.44 ± 0.36

1.74 ± 0.31*

1.38 ± 0.44

1.26 ± 0.28

2.12 ± 0.59*

1.14 ± 0.10*

2.05 ± 1.49

 Pra

7.9 ± 1.2

7.3 ± 1.7

8.5 ± 1.4*

8.6 ± 1.8*

9.0 ± 2.1

9.9 ± 1.2*

6.8 ± 1.5*

6.5 ± 0.7

 Pmsa

13.2 ± 1.2

12.6 ± 1.8

15.2 ± 1.3*

14.5 ± 1.8*

15.1 ± 2.1*

15.4 ± 1.5

15.4 ± 2.1

11.7 ± 1.7

 Pvr

5.3 ± 0.5

5.3 ± 0.4

6.7 ± 0.5*

6.0 ± 0.6

6.7 ± 0.4*

5.7 ± 0.8

8.8 ± 0.8*

5.7 ± 0.8

 Eh

0.41 ± 0.05

0.42 ± 0.57

0.44 ± 0.05*

0.42 ± 0.06

0.45 ± 0.06

0.37 ± 0.04*

0.57 ± 0.04*

0.49 ± 0.03

 SW

2736 ± 963

2311 ± 723

6171 ± 2284*

3722 ± 1577*

6789 ± 1923*

3480 ± 1389

6411 ± 2131*

3019 ± 978

 LV efficiency

0.67 ± 0.11

0.61 ± 0.12

0.74 ± 0.07*

0.73 ± 0.15*

0.68 ± 0.09

0.66 ± 0.15

0.70 ± 0.04

0.60 ± 0.11

CI > 15%

Variable

Responders

Not Responders

Responders

Not Responders

Responders

Not Responders

Responders

Not Responders

 Patients

49

6

7

14

5

3

 SAP

83 ± 20

66 ± 22

115 ± 29*

81 ± 34

103 ± 25

118 ± 34*

118 ± 32

122 ± 18

 DAP

44 ± 10

51 ± 8

43 ± 15

51 ± 12

46 ± 1*

35 ± 14*

46 ± 14

35 ± 5

 MAP

57 ± 3

56 ± 2

67 ± 6*

61 ± 4*

72 ± 2

62 ± 7

70 ± 2*

64 ± 8

 PPV

16.0 ± 1.8

12.7 ± 2.3

11.4 ± 1.3*

11.8 ± 1.2

11.0 ± 1.4

11.1 ± 0.7*

11.3 ± 0.6

10.3 ± 0.6

 CI

2.09 ± 0.12

2.07 ± 0.52

2.58 ± 0.16*

2.28 ± 0.12*

2.70 ± 0.17*

2.45 ± 0.23

2.86 ± 0.05*

2.70 ± 0.44*

 HR

112 ± 7

119 ± 5

94 ± 12*

108 ± 11*

108 ± 13

105 ± 14

91 ± 8

102 ± 16

 SV

34.5 ± 5.2

34.9 ± 2.9

51.4 ± 10.0*

43.2 ± 8.9*

47.4 ± 9.4

44.6 ± 9.9

54.2 ± 10.3*

50.7 ± 15.7

 SVV

18.3 ± 3.1

19.7 ± 2.0

13.0 ± 3.5*

14.3 ± 4.2*

8.0 ± 2.8

11.3 ± 2.8*

11.7 ± 2.9

10.3 ± 0.6

 Ea_dyn

0.91 ± 0.20

0.65 ± 1.56

0.92 ± 0.20

0.89 ± 0.27

1.50 ± 0.70

1.04 ± 0.31*

1.01 ± 0.24

1.00 ± 0.10

 Ees

1.44 ± 0.37

1.25 ± 0.15

1.67 ± 0.34*

1.48 ± 0.20*

1.70 ± 0.20

1.41 ± 0.35

1.70 ± 0.10*

1.43 ± 0.48

 Ea

2.16 ± 0.37

1.70 ± 0.48

2.02 ± 0.33*

1.65 ± 0.34

1.83 ± 0.21

2.36 ± 0.36*

1.93 ± 0.15

2.27 ± 0.46

 Ea/Ees

1.57 ± 0.39

1.44 ± 0.61

1.27 ± 0.36*

1.15 ± 0.38

1.09 ± 0.17

1.80 ± 0.62*

1.14 ± 0.12

1.82 ± 1.12

 Pra

7.7 ± 1.4

7.2 ± 1.3

8.3 ± 1.4*

10.5 ± 1.2*

8.0 ± 1.7

9.3 ± 1.7*

5.8 ± 0.8*

7.3 ± 1.5 *

 Pmsa

13.1 ± 1.4

12.4 ± 1.4

14.8 ± 1.5*

16.1 ± 1.3*

14.5 ± 1.4*

15.4 ± 1.8*

13.2 ± 1.9

15.4 ± 3.3

 Pvr

5.3 ± 0.5

5.2 ± 0.3

6.5 ± 0.7*

5.6 ± 0.4*

6.5 ± 0.3*

6.1 ± 0.8

7.4 ± 1.6

8.1 ± 2.0

 Eh

0.41 ± 1.47

0.42 ± 0.04

0.44 ± 0.50*

0.35 ± 0.03*

0.45 ± 0.07*

0.40 ± 0.06*

0.56 ± 0.06*

0.52 ± 0.04*

 SW

2639 ± 902

2115 ± 808

5535 ± 2267

3373 ± 2294

4507 ± 1900

4965 ± 2415*

5932 ± 2804

5759 ± 2448

 LV efficiency

0.65 ± 0.12

0.62 ± 0.08

0.73 ± 0.10*

0.80 ± 0.14*

0.77 ± 0.09

0.66 ± 0.12

0.71 ± 0.05

0.66 ± 0.06