Mechanical ventilation causes diaphragm dysfunction in newborn lambs

Table 1 Ventilator settings and gas exchange parameters in the two groups of newborn lambs receiving mechanical ventilation

Respiratory parameters	MV (N = 6)	MV+SD (N = 6)
Respiratory rate (bpm)	60 (59–60)	53 (47–56)^a
Tidal volume (ml/kg)	7.8 (7.7–7.9)	5.9 (5.7–6.6)^a
FiO₂ (%)	25 (22–25)	71 (60–95)^a
PEEP (cmH₂O)	6.0 (5.3–6.0)	6.0 (5.3–6.0)
Peak inspiratory airway pressure (cmH₂O)	16.0 (15.0–16.0)	17.0 (14.8–18.5)
Arterial pH	7.33 (7.31–7.37)	7.26 (7.16–7.28)^b
PaO₂ (mmHg)	63 (52–67)	97 (92–110)^a
PaCO₂ (mmHg)	46 (45–50)	48 (39–49)
PaO₂/FiO₂ ratio	271 (232–283)	142 (105–161)^a
Dynamic compliance (ml/kg/cmH₂O)	0.77 (0.68–0.79)	0.58 (0.48–0.69)^a

Dynamic compliance = tidal volume/peak inspiratory airway pressure minus PEEP. Data are reported as median (interquartiles) after 5 h of mechanical ventilation
PEEP positive end-expiratory pressure, FiO2 fraction of inspired oxygen
^ap < 0.01 or ^bp < 0.05 (rank test)

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