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Fig. 1 | Critical Care

Fig. 1

From: Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis

Fig. 1

Infant mice are more susceptible than adult mice to sepsis. a Infant and adult mice were injected with microbial suspension (2 × 108 CFU/cavity), and the survival was recorded for 5 days. b Bacterial counts in the blood. c Serum concentration of TNF-α was determined by ELISA 6 h after sepsis induction. The enzymatic activity of CK-MB (measure of heart damage) (d) and BUN (measure of kidney damage) (e) in the serum were determined. f Representative histology of lung sections is shown, magnification ×40. Bars = 100 μm. Data are mean ± SEM, n = 5–6 per group and are representative of two to three independent experiments. **p < 0.01, ***p < 0.001 (a, Mantel-Cox log-rank test; be one-way ANOVA, Bonferroni’s), n.d. = not detectable

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