PO2 oscillations induce lung injury and inflammation

Table 3 Results of “lung injury scoring” parameters

Lung injury score (LIS) parameters—median (Q1; Q3)
	Control	Intervention	P value
(i) Neutrophils in alveolar space	0.04 (0.01; 0.08)	0.2 (0.18; 0.24)	0.0013
(ii) Neutrophils in interstitial space	0.16 (0.13; 0.16)	0.22 (0.21; 0.23)	0.0025
(iii) Hyaline membranes	0.008 (0; 0.04)	0.05 (0.01; 0.06)	0.1768
(iv) Protein detrius in alveolar space	0.008 (0; 0.016)	0.04 (0.02; 0.05)	0.0025
(v) Septum thickening	0.01 (0.01; 0.01)	0.02 (0.02; 0.02)	0.0303

Lung injury scoring (LIS) itemized for the following judged factors of (i) neutrophils in alveolar space, (ii) neutrophils in interstitial space, (iii) hyaline membranes, (iv) protein detritus in alveolar space, and (v) septum thickening. Score per field was assessed semi quantitatively: (i) was scored 0 if none, 1 if 1 to 5, and 2 if higher 5; (ii) was scored 0 if none, 1 if 1 to 10, and 2 if higher 10; (iii) was scored 0 if none, 1 if 1, and 2 if higher 1; (iv) was scored 0 if none, 1 if 1, and 2 if higher 1; (v) was scored 0 if none, 1 if 2 to 4, and 2 if 5 or higher. For LIS calculation, the factors (i) to (v) were weighted by the following formula: [20 × (i) + 14 × (ii) + 7 × (iii) + 7 × (iv) + 2 × (v)]/100. Results are presented as median with 25% and 75% percentile (Q1; Q3). P value: Wilcoxon signed-rank test

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